神经系统疾病模型系统。
: A Model System for Neurological Disorders.
机构信息
Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Bundoora 3086, Australia.
Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.
出版信息
Cells. 2022 Jan 28;11(3):463. doi: 10.3390/cells11030463.
BACKGROUND
The incidence of neurological disorders is increasing due to population growth and extended life expectancy. Despite advances in the understanding of these disorders, curative strategies for treatment have not yet eventuated. In part, this is due to the complexities of the disorders and a lack of identification of their specific underlying pathologies. has provided a useful, simple model to aid in unraveling the complex pathological characteristics of neurological disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, neuronal ceroid lipofuscinoses and lissencephaly. In addition, has proven to be an innovative model for pharmaceutical research in the neurological field.
SCOPE OF REVIEW
This review describes the contributions of in the field of neurological research. The continued exploration of proteins implicated in neurological disorders in may elucidate their pathological roles and fast-track curative therapeutics.
背景
由于人口增长和预期寿命延长，神经紊乱的发病率正在上升。尽管对这些疾病的认识有了进步，但还没有出现治疗的治愈策略。部分原因是由于这些疾病的复杂性以及缺乏对其特定潜在病理学的识别。果蝇模型为帮助揭示包括阿尔茨海默病、帕金森病、亨廷顿病、神经元蜡样脂褐质沉积症和无脑回畸形在内的神经紊乱的复杂病理特征提供了一个有用、简单的模型。此外，果蝇模型已被证明是神经科学领域药物研究的创新模型。
综述范围
本文描述了果蝇模型在神经科学研究领域的贡献。在果蝇模型中继续探索与神经紊乱相关的蛋白质，可能阐明其病理作用，并加速治疗方法的研发。
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