Choi Rihwa, Lee Sang Gon, Lee Eun Hee
Department of Laboratory Medicine, Green Cross Laboratories, Yongin 16924, Korea.
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
J Clin Med. 2022 Feb 4;11(3):832. doi: 10.3390/jcm11030832.
Limited data are available on test utilization and intraindividual changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) in Korean patients that visit local clinics and hospitals. We retrospectively reviewed longitudinally measured RF and anti-CCP data in Korean patients to investigate the utilization and changes in test results through a laboratory information system. During the 10-year study period, 256,259 specimens were tested for RF. Among them, 32,567 (12.7%) specimens from 31,110 Korean adults had simultaneously measured anti-CCP results. Among them, 1110 (3.6%) subjects had follow-up test results. Among 351 patients with initial positive RF results, 290 (82.6%) had no qualitative change in RF from positive to negative values during follow-up. About 3.8% (29/759) of patients with initial negative results experienced qualitative changes in RF that were positive on follow-up. Among 182 patients with an anti-CCP-positive result at initial measurement, 174 (95.6%) had no qualitative change in anti-CCP from positive to negative or equivocal results during follow-up. About 0.5% (5/928) of patients with initial negative values experienced qualitative changes in anti-CCP to positive values on follow-up. The agreement of qualitative results between RF and anti-CCP was 80.8% (95% confidence interval 78.4-83.1%) at initial measurement and 80.6% (95% confidence interval 79.0-82.1%) overall. The results of this study can help inform utilization of RF and anti-CCP testing for Korean patients visiting local clinics and hospitals.
关于在韩国当地诊所和医院就诊的患者中类风湿因子（RF）和抗环瓜氨酸肽抗体（抗CCP）的检测利用情况以及个体内变化的数据有限。我们回顾性地分析了韩国患者纵向测量的RF和抗CCP数据，以通过实验室信息系统研究检测的利用情况和检测结果的变化。在10年的研究期间，共检测了256,259份标本的RF。其中，来自31,110名韩国成年人的32,567份标本（12.7%）同时检测了抗CCP结果。其中，1110名受试者（3.6%）有后续检测结果。在351例初始RF结果为阳性的患者中，290例（82.6%）在随访期间RF从阳性变为阴性的定性结果无变化。约3.8%（29/759）初始结果为阴性的患者在随访期间RF出现了定性变化，变为阳性。在182例初始抗CCP检测结果为阳性的患者中，174例（95.6%）在随访期间抗CCP从阳性变为阴性或不确定结果的定性结果无变化。约0.5%（5/928）初始抗CCP值为阴性的患者在随访期间抗CCP出现定性变化，变为阳性。RF和抗CCP定性结果的一致性在初始检测时为80.8%（95%置信区间78.4 - 83.1%），总体为80.6%（95%置信区间79.0 - 82.1%）。本研究结果有助于为韩国当地诊所和医院就诊患者的RF和抗CCP检测利用提供参考。
