Mat Isa Siti Zaleha, Zainon Rafidah, Tamal Mahbubunnabi
Department of Biomedical Imaging, Advanced Medical and Dental Institute, Universiti Sains Malaysia, SAINS@BERTAM, Kepala Batas 13200, Pulau Pinang, Malaysia.
Department of Biomedical Engineering, College of Engineering, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Materials (Basel). 2022 Jan 24;15(3):875. doi: 10.3390/ma15030875.
With recent advances in nanotechnology, various nanomaterials have been used as drug carriers in molecular imaging for the treatment of cancer. The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose. The conventional gold nanoparticles synthetisation methods have limitations with chemical contaminations during the synthesisation process and the use of higher energy. Thus, various innovative approaches in gold nanoparticles synthetisation are under development. Recently, studies have been focused on the development of eco-friendly, non-toxic, cost-effective and simple gold nanoparticle synthesisation. The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle. Therefore, this study aimed to review the eco-friendly gold nanoparticle synthesisation method via the PLAL method and to characterise the gold nanoparticles properties for molecular imaging. This review paper provides new insight to understand the PLAL technique in producing gold nanoparticles and the PLAL parameters that affect gold nanoparticle properties to meet the desired needs in molecular imaging.
随着纳米技术的最新进展，各种纳米材料已被用作分子成像中的药物载体用于癌症治疗。金纳米颗粒独特的物理化学性质和生物相容性在分子成像方面取得了突破，这使得金纳米颗粒在用于诊断目的的药物递送中得到探索。传统的金纳米颗粒合成方法在合成过程中存在化学污染以及使用较高能量的局限性。因此，金纳米颗粒合成的各种创新方法正在开发中。最近，研究集中在开发环保、无毒、经济高效且简单的金纳米颗粒合成方法。液体中的脉冲激光烧蚀（PLAL）技术是一种通用的合成技术且令人信服，因为它具有高效率、环保且简便的方法来制备金纳米颗粒。因此，本研究旨在综述通过PLAL方法合成环保型金纳米颗粒的方法，并表征用于分子成像的金纳米颗粒的性质。这篇综述文章为理解PLAL技术在制备金纳米颗粒中的应用以及影响金纳米颗粒性质以满足分子成像所需的PLAL参数提供了新的见解。
