Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-598, RJ, Brazil.
National Institute of Health Quality Control, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil.
Int J Environ Res Public Health. 2022 Jan 22;19(3):1211. doi: 10.3390/ijerph19031211.
Polycyclic aromatic hydrocarbons (PAHs) are persistent pollutants routinely detected in aquatic ecosystems. It is, therefore, necessary to assess the link between deleterious marine biota PAH effects, especially in commercialized and consumed animals, environmental health status, and potential human health risks originating from the consumption of contaminated seafood products. Thus, this review seeks to verify the relationships of ecotoxicological studies in determining effect and safety concentrations on animals routinely consumed by humans.
A total of 52 published studies between 2011 and 2021, indexed in three databases, were selected following the PICO methodology, and information on test animals, evaluated PAH, and endpoints were extracted.
Benzo(a)pyrene and phenanthrene were the most investigated PAHs in terms of biomarkers and test organisms, and mussels were the most evaluated bioindicator species, with an emphasis on reproductive responses. Furthermore, despite the apparent correlation between environmental PAH dynamics and effects on aquatic biota and human health, few assessments have been performed in a multidisciplinary manner to evaluate these three variables together.
The links between human and environmental sciences must be strengthened to enable complete and realistic toxicity assessments as despite the application of seafood assessments, especially to mussels, in bioassays, the connection between toxicological animal responses and risks associated with their consumption is still understudied.
多环芳烃（PAHs）是在水生生态系统中经常检测到的持久性污染物。因此，有必要评估有害海洋生物 PAH 影响与环境健康状况之间的联系，特别是在商业化和食用的动物中，以及源自食用受污染海鲜产品的潜在人类健康风险。因此，本综述旨在验证生态毒理学研究在确定常规食用动物的效应和安全浓度方面的关系。
共选择了 2011 年至 2021 年期间在三个数据库中索引的 52 项已发表研究，采用 PICO 方法进行筛选，并提取了有关测试动物、评估的 PAH 和终点的信息。
苯并[a]芘和菲是在生物标志物和测试生物中研究最多的 PAHs，贻贝是评估最多的生物指示物种，重点是繁殖反应。此外，尽管环境 PAH 动态与水生生物和人类健康的影响之间存在明显的相关性，但很少有以多学科方式进行评估以一起评估这三个变量。
必须加强人类与环境科学之间的联系，以实现全面和现实的毒性评估，尽管在生物测定中已经应用了海鲜评估，特别是贻贝，但毒理学动物反应与与食用相关的风险之间的联系仍在研究中。
