Gerstenberg T C, Klarskov P, Ramirez D, Hald T
Br J Urol. 1986 Apr;58(2):129-33. doi: 10.1111/j.1464-410x.1986.tb09011.x.
In a consecutive double-blind cross-over study, 18 females with detrusor instability were treated with an anticholinergic and calcium antagonistic agent terodiline 25 mg bid or placebo for 3 weeks; cross-over took place after a wash-out period of 1 week. The efficacy of the drug was investigated at the end of each treatment period by means of drug preference, micturition charts, pad usage, bladder and urethral mucosal perception threshold and bulbocavernosus reflex latency measurement. Serum levels of terodiline were estimated at the end of each treatment period and all side effects were reported. The preference for the drug was statistically significant (P less than 0.01): 14 patients preferred the drug, one preferred the placebo and three had no preference. A small but statistically significant reduction was found in 24-h micturition frequency (P less than 0.05). Cystometry showed an increase in volume at first sensation, an increase in volume at detrusor contraction and a tendency towards an increase in bladder capacity, whereas detrusor contraction pressure was unchanged. Median serum levels of the drug were 559 ng/ml (range 203-1117). No serious side effects were reported. It was concluded that terodiline should be considered as an alternative drug in the treatment of motor urge incontinence.
在一项连续双盲交叉研究中，18名逼尿肌不稳定的女性患者接受了抗胆碱能和钙拮抗药物特罗地林25毫克，每日两次，或安慰剂治疗，为期3周；在1周的洗脱期后进行交叉治疗。在每个治疗期结束时，通过药物偏好、排尿图表、护垫使用情况、膀胱和尿道黏膜感觉阈值以及球海绵体反射潜伏期测量来研究药物的疗效。在每个治疗期结束时估计特罗地林的血清水平，并报告所有副作用。对药物的偏好具有统计学意义（P小于0.01）：14名患者更喜欢药物，1名更喜欢安慰剂，3名无偏好。24小时排尿频率有小幅但具有统计学意义的降低（P小于0.05）。膀胱测压显示初感容量增加、逼尿肌收缩时容量增加以及膀胱容量有增加趋势，而逼尿肌收缩压力未变。药物的血清中位数水平为559纳克/毫升（范围203 - 1117）。未报告严重副作用。结论是特罗地林应被视为治疗运动性急迫性尿失禁的替代药物。
