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一种钙阻滞剂和抗胆碱能药物(特罗地林)治疗逼尿肌反射亢进:一项安慰剂对照交叉试验

A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial.

作者信息

Petersen T, Jakobsen J

机构信息

Department of Neurology, University Hospital of Aarhus, Denmark.

出版信息

J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1331-6. doi: 10.1136/jnnp.50.10.1331.

DOI:10.1136/jnnp.50.10.1331
PMID:3681312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032460/
Abstract

In 25 neurological patients with detrusor hyperreflexia terodiline reduced the number of total micturitions during daytime. Bladder capacity was increased and amplitude of the bladder contractions was reduced. An increase in residual urine was also observed. Mild anticholinergic side-effects were measured on pupillary motility and on heart rate variation. It is concluded that terodiline is a useful alternative in treatment of patients with detrusor hyperreflexia.

摘要

在25例患有逼尿肌反射亢进的神经科患者中,特罗地林减少了白天总的排尿次数。膀胱容量增加,膀胱收缩幅度减小。还观察到残余尿量增加。在瞳孔运动和心率变化方面检测到轻微的抗胆碱能副作用。得出的结论是,特罗地林是治疗逼尿肌反射亢进患者的一种有用的替代药物。

相似文献

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A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial.一种钙阻滞剂和抗胆碱能药物(特罗地林)治疗逼尿肌反射亢进:一项安慰剂对照交叉试验
J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1331-6. doi: 10.1136/jnnp.50.10.1331.
2
Terodiline in the treatment of women with urgency and motor urge incontinence. A clinical and urodynamic double-blind cross-over study.特罗地林治疗女性急迫性和运动性急迫性尿失禁。一项临床和尿动力学双盲交叉研究。
Br J Urol. 1986 Apr;58(2):129-33. doi: 10.1111/j.1464-410x.1986.tb09011.x.
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[Clinical effects of terodiline hydrochloride on urinary frequency and sense of residual urine--a double blind clinical trial using flavoxate hydrochloride as a control].盐酸特罗地林对尿频及残余尿感的临床疗效——以盐酸黄酮哌酯为对照的双盲临床试验
Hinyokika Kiyo. 1988 Apr;34(4):739-53.
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J Oslo City Hosp. 1989 Jun-Jul;39(6-7):67-73.
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[Clinical study of terodiline hydrochloride for the treatment of urinary frequency and urinary incontinence, and its cardiovascular adverse effects].盐酸特罗地林治疗尿频和尿失禁及其心血管不良反应的临床研究
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Ann Chir Gynaecol. 1987;76(2):128-32.
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[Clinical effects of terodiline hydrochloride for urinary frequency and sense of residual urine].盐酸特罗地林治疗尿频及残余尿感的临床疗效
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引用本文的文献

1
Tolerability and steady-state pharmacokinetics of terodiline and its main metabolites in elderly patients with urinary incontinence.替地罗新及其主要代谢产物在老年尿失禁患者中的耐受性和稳态药代动力学
Eur J Clin Pharmacol. 1989;36(5):487-93. doi: 10.1007/BF00558074.
2
Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence.特罗地林。其药理特性及治疗尿失禁的应用综述。
Drugs. 1990 Nov;40(5):748-61. doi: 10.2165/00003495-199040050-00008.
3
Terodiline causes polymorphic ventricular tachycardia due to reduced heart rate and prolongation of QT interval.特罗地林因心率降低和QT间期延长而导致多形性室性心动过速。
Eur J Clin Pharmacol. 1992;42(6):577-80. doi: 10.1007/BF00265918.

本文引用的文献

1
Mutual role of sympathetic and parasympathetic in shaping of the pupillary reflex to light; pupillographic studies.交感神经和副交感神经在形成瞳孔对光反射中的相互作用;瞳孔描记法研究。
Arch Neurol Psychiatry. 1950 Sep;64(3):341-77. doi: 10.1001/archneurpsyc.1950.02310270030002.
2
Cystometric response to propantheline in detrusor hyperreflexia: therapeutic implications.逼尿肌反射亢进时对丙胺太林的膀胱测压反应:治疗意义
J Urol. 1980 Aug;124(2):259-62. doi: 10.1016/s0022-5347(17)55398-7.
3
Anticholinergic and calcium antagonistic effects of terodiline in rabbit urinary bladder.特罗地林对兔膀胱的抗胆碱能和钙拮抗作用
Acta Pharmacol Toxicol (Copenh). 1980;46 Suppl 1:20-30. doi: 10.1111/j.1600-0773.1980.tb03244.x.
4
Dynamic motor capacity in spastic paresis and its relation to prime mover dysfunction, spastic reflexes and antagonist co-activation.
Scand J Rehabil Med. 1980;12(3):93-106.
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Clinical pharmacology of terodiline.特罗地林的临床药理学
Scand J Urol Nephrol Suppl. 1984;87:13-20.
6
Neurourodynamic evaluation of voiding dysfunction in multiple sclerosis.多发性硬化症排尿功能障碍的神经尿动力学评估
Acta Neurol Scand. 1984 Jun;69(6):402-11. doi: 10.1111/j.1600-0404.1984.tb07823.x.
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Heart rate variation in patients treated with antidepressants. An index of anticholinergic effects?
Psychopharmacology (Berl). 1984;84(4):544-8. doi: 10.1007/BF00431464.
8
Oxybutynin versus propantheline in patients with multiple sclerosis and detrusor hyperreflexia.奥昔布宁与丙胺太林治疗多发性硬化症合并逼尿肌反射亢进的疗效比较
J Urol. 1986 May;135(5):966-8. doi: 10.1016/s0022-5347(17)45940-4.
9
Relation between flexor spasms, uninhibited detrusor contractions and anal sphincter activity.屈肌痉挛、逼尿肌无抑制性收缩与肛门括约肌活动之间的关系。
J Neurol Neurosurg Psychiatry. 1986 Mar;49(3):273-7. doi: 10.1136/jnnp.49.3.273.
10
Bladder training and terodiline in females with idiopathic urge incontinence and stable detrusor function.膀胱训练与特罗地林治疗特发性急迫性尿失禁且逼尿肌功能稳定的女性患者
Scand J Urol Nephrol. 1986;20(1):41-6. doi: 10.3109/00365598609024478.