Bihler I, Charles P, Sawh P C
Can J Physiol Pharmacol. 1986 Feb;64(2):176-9. doi: 10.1139/y86-026.
Hexose transport in isolated perifused rat and guinea pig left atria and in isolated intact rat hemidiaphragms was followed by measuring the tissue/medium distribution of the nonmetabolized glucose analog, 3-O-methyl-D-glucose. Stimulation of 3-methylglucose transport by insulin, hyperosmolar medium, K+-free medium, and ouabain was depressed or absent in Ca2+-free medium. Addition of 2 mM Sr2+ to Ca2+-free media restored the response of transport to the stimulatory factors. Sr2+ also increased basal hexose transport. The Ca2+ dependence and the effect of Sr2 was greatest in guinea pig atria and least in rat hemidiaphragms. It is concluded that Sr2+ plays a Ca2+-like role in the regulation of hexose transport.
通过测量非代谢性葡萄糖类似物3 - O - 甲基 - D - 葡萄糖在组织/培养基中的分布，来跟踪分离的灌注大鼠和豚鼠左心房以及分离的完整大鼠半膈肌中的己糖转运。在无钙培养基中，胰岛素、高渗培养基、无钾培养基和哇巴因对3 - 甲基葡萄糖转运的刺激作用减弱或消失。向无钙培养基中添加2 mM Sr²⁺可恢复转运对刺激因子的反应。Sr²⁺还增加了基础己糖转运。Ca²⁺依赖性以及Sr²⁺的作用在豚鼠心房中最大，在大鼠半膈肌中最小。得出的结论是，Sr²⁺在己糖转运调节中起类似Ca²⁺的作用。
