Cell Activation and Gene Expression Group, Instituto de Biologia Molecular e Celular (IBMC), Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Department of Medical Sciences, University of Aveiro (UA), 3810-193 Aveiro, Portugal.
Int J Mol Sci. 2022 Jan 31;23(3):1640. doi: 10.3390/ijms23031640.
Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit preponderant immunomodulatory properties. The ultimate protective or deleterious functions displayed by iNKT cells in tissues are known to be partially shaped by the interactions they establish with other immune cells. In particular, the iNKT cell-macrophage crosstalk has gained growing interest over the past two decades. Accumulating evidence has highlighted that this immune axis plays central roles not only in maintaining homeostasis but also during the development of several pathologies. Hence, this review summarizes the reported features of the iNKT cell-macrophage axis in health and disease. We discuss the pathophysiological significance of this interplay and provide an overview of how both cells communicate with each other to regulate disease onset and progression in the context of infection, obesity, sterile inflammation, cancer and autoimmunity.
不变自然杀伤 T(iNKT)细胞是 CD1d 限制性、脂类反应性 T 细胞，具有明显的免疫调节特性。已知 iNKT 细胞在组织中表现出的最终保护或有害功能部分是由它们与其他免疫细胞建立的相互作用所决定的。特别是，iNKT 细胞-巨噬细胞相互作用在过去二十年中引起了越来越多的关注。越来越多的证据表明，这个免疫轴不仅在维持内稳态中起着核心作用，而且在几种病理过程的发展中也起着核心作用。因此，本综述总结了 iNKT 细胞-巨噬细胞轴在健康和疾病中的报道特征。我们讨论了这种相互作用的病理生理学意义，并概述了这两种细胞如何相互沟通，以调节感染、肥胖、无菌性炎症、癌症和自身免疫性疾病背景下疾病的发生和进展。
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