Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Int J Mol Sci. 2022 Feb 8;23(3):1919. doi: 10.3390/ijms23031919.
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.
代谢重编程是癌症的一个标志。癌细胞重新布线一碳代谢，这是一种中心代谢途径，将营养输入转化为癌细胞生长和维持所需的必需生物分子。放射治疗是一种常见的癌症治疗方法，也会相互作用并改变一碳代谢。本文讨论了放射治疗、一碳代谢及其组成代谢途径之间的相互作用。
