Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.
Mol Cell. 2020 Jun 18;78(6):1034-1044. doi: 10.1016/j.molcel.2020.05.018. Epub 2020 Jun 5.
Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation. These demands lead to differential requirements in energy, biosynthetic precursors, and signaling intermediates. Both genetic programs arising from oncogenic events and transcriptional programs and epigenomic events are important in providing the necessary metabolic network activity. Accumulating evidence has established that environmental factors play a major role in shaping cancer cell metabolism. For metabolism, diet and nutrition are the major environmental aspects and have emerged as key components in determining cancer cell metabolism. In this review, we discuss these emerging concepts in cancer metabolism and how diet and nutrition influence cancer cell metabolism.
恶性细胞重塑其代谢以满足不受控制的细胞增殖的需求。这些需求导致在能量、生物合成前体和信号中间体方面存在差异。致癌事件引起的遗传程序以及转录程序和表观遗传事件在提供必要的代谢网络活性方面都很重要。越来越多的证据已经确立，环境因素在塑造癌细胞代谢方面起着主要作用。对于代谢而言，饮食和营养是主要的环境方面，并已成为决定癌细胞代谢的关键组成部分。在这篇综述中，我们讨论了癌症代谢中的这些新出现的概念，以及饮食和营养如何影响癌细胞代谢。
