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-氨基膦酸酯和 3-乙酰基-1-氨基喹啉-2（）-酮亚胺衍生物对 DMBA 诱导的乳腺癌的抗癌作用研究及其胸苷酸合成酶抑制作用的计算机预测。

Investigation of the Anticancer Effect of -Aminophosphonates and Arylidine Derivatives of 3-Acetyl-1-aminoquinolin-2()-one on the DMBA Model of Breast Cancer in Albino Rats with In Silico Prediction of Their Thymidylate Synthase Inhibitory Effect.

机构信息

Department of Clinical Laboratory Sciences, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Department of Chemistry, Turabah University College, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

出版信息

Molecules. 2022 Jan 24;27(3):756. doi: 10.3390/molecules27030756.

DOI:10.3390/molecules27030756
PMID:35164019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8839308/
Abstract

Breast cancer is a major cause of death in women worldwide. In this study, 60 female rats were classified into 6 groups; negative control, -aminophosphonates, arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one, DMBA, DMBA & -aminophosphonates, and DMBA & arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one. New -aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one were synthesized and elucidated by different spectroscopic and elemental analysis. Histopathological examination showed marked proliferation of cancer cells in the DMBA group. Treatment with -aminophosphonates mainly decreased tumor mass. Bcl2 expression increased in DMBA-administered rats and then declined in the treated groups, mostly with α-aminophosphonates. The level of CA15-3 markedly declined in DMBA groups treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one. Gene expression of GST-P, PCNA, PDK, and PIK3CA decreased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one, whereas PIK3R1 and BAX increased in the DMBA group treated with α-aminophosphonates and arylidine derivatives of 3-acetyl-1-aminoquinolin-2()-one. The molecular docking postulated that the investigated compounds can inhibt the Thymidylate synthase TM due to high hydrophobicity charachter.

摘要

乳腺癌是全球女性死亡的主要原因之一。在这项研究中，将 60 只雌性大鼠分为 6 组：阴性对照组、-氨基膦酸酯、3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物、DMBA、DMBA 和 -氨基膦酸酯以及 DMBA 和 3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物。新的 -氨基膦酸酯和 3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物通过不同的光谱和元素分析进行了阐明。组织病理学检查显示 DMBA 组癌细胞明显增殖。-氨基膦酸酯治疗主要减少肿瘤质量。Bcl2 表达在 DMBA 给药大鼠中增加，然后在治疗组中下降，主要是与α-氨基膦酸酯一起下降。用 α-氨基膦酸酯和 3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物治疗 DMBA 组的 CA15-3 水平明显下降。用 α-氨基膦酸酯和 3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物治疗 DMBA 组 GST-P、PCNA、PDK 和 PIK3CA 的基因表达下降，而 PIK3R1 和 BAX 在 DMBA 组中增加用 α-氨基膦酸酯和 3-乙酰-1-氨基喹啉-2（）酮的亚胺衍生物治疗。分子对接假定，所研究的化合物由于高疏水性特征，可以抑制胸苷酸合成酶 TM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/78c616360ac1/molecules-27-00756-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/f4364ceab93f/molecules-27-00756-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/68d606dc19a7/molecules-27-00756-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/47761bf4d6da/molecules-27-00756-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/0bc92fcbc677/molecules-27-00756-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/307a73751a0d/molecules-27-00756-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/11e55c6a9649/molecules-27-00756-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/210350381b24/molecules-27-00756-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/3f78d7738fa0/molecules-27-00756-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/78c616360ac1/molecules-27-00756-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/f4364ceab93f/molecules-27-00756-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/68d606dc19a7/molecules-27-00756-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/47761bf4d6da/molecules-27-00756-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/0bc92fcbc677/molecules-27-00756-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/307a73751a0d/molecules-27-00756-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/11e55c6a9649/molecules-27-00756-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/210350381b24/molecules-27-00756-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/3f78d7738fa0/molecules-27-00756-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502a/8839308/78c616360ac1/molecules-27-00756-g007.jpg

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Pharmaceutics. 2023-5-11

[2]
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Drug Des Devel Ther. 2022

[4]
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Materials (Basel). 2022-5-27

本文引用的文献

[1]
PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway.

Ann Transl Med. 2021-3

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Cancers (Basel). 2021-1-26

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Int J Mol Sci. 2020-12-26

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Bioorg Chem. 2020-9

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Front Oncol. 2020-4-30

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Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.

BMC Pharmacol Toxicol. 2020-2-10

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Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease.

Bioorg Chem. 2020-3

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LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer.

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