氟桂利嗪-苯噻啶预防偏头痛的单剂量双盲交叉试验。

Flunarizine-pizotifen single-dose double-blind cross-over trial in migraine prophylaxis.

作者信息

Cerbo R, Casacchia M, Formisano R, Feliciani M, Cusimano G, Buzzi M G, Agnoli A

出版信息

Cephalalgia. 1986 Mar;6(1):15-8. doi: 10.1046/j.1468-2982.1986.0601015.x.

DOI:10.1046/j.1468-2982.1986.0601015.x

Abstract

The results of a double-blind cross-over clinical trial involving 27 patients with classical or common migraine are described to compare the prophylactic effect of the calcium entry blocker flunarizine with that of pizotifen. Duration of the treatment was two months, with an evening single-dose administration of both drugs. For most parameters, there was no definite difference between flunarizine and pizotifen in migraine prophylaxis. It has been demonstrated previously that pizotifen is an effective drug in migraine prophylaxis, and these results suggest that flunarizine is effective, too. Weight gain as a side effect was less frequent and less severe with flunarizine than with pizotifen; other side effects showed the same incidence with both drugs.

摘要

本文描述了一项双盲交叉临床试验的结果，该试验涉及27名典型偏头痛或普通偏头痛患者，旨在比较钙通道阻滞剂氟桂利嗪和苯噻啶的预防效果。治疗持续时间为两个月，两种药物均在晚上单次给药。对于大多数参数，氟桂利嗪和苯噻啶在偏头痛预防方面没有明显差异。先前已经证明苯噻啶是一种有效的偏头痛预防药物，这些结果表明氟桂利嗪也有效。与苯噻啶相比，氟桂利嗪作为副作用的体重增加不太频繁且不太严重；两种药物的其他副作用发生率相同。