CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44's gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.