Genin C, Michael A F
Clin Immunol Immunopathol. 1986 Jun;39(3):504-13. doi: 10.1016/0090-1229(86)90177-7.
Prior studies have demonstrated that following administration to animals most antigens (Ag) localize within the red pulp whereas immune complexes (IC) are found in the white pulp. Using ferritin and ferritin IC, we describe a striking different localization of the Ag alone compared with the same AG complexed with its antibody. In addition, cationization of native ferritin (pI 4.5) to cationized ferritin (pI 7) decreases significantly the splenic uptake of the Ag but has no effect on the uptake of the respective ferritin IC by the white pulp.
先前的研究表明，给动物注射后，大多数抗原（Ag）定位于红髓，而免疫复合物（IC）则存在于白髓中。使用铁蛋白和铁蛋白免疫复合物，我们描述了单独的抗原与与其抗体复合的相同抗原相比，其定位存在显著差异。此外，将天然铁蛋白（pI 4.5）阳离子化为阳离子化铁蛋白（pI 7）可显著降低脾脏对抗原的摄取，但对白髓对相应铁蛋白免疫复合物的摄取没有影响。
