VA Boston Healthcare System, 150 South Huntington Avenue, Boston, MA, 02130, USA.
BMC Res Notes. 2022 Feb 14;15(1):45. doi: 10.1186/s13104-022-05912-9.
A novel graph data model of non-small cell lung cancer clinical and genomic data has been constructed with two aims: (1) provide a suitable model for facilitating graph analytics within the Neo4j framework or through tools which can interact through existing Neo4j APIs; and (2) provide a base model extensible to other cancer types and additional datasets such as those derived from electronic health records and other real world sources.
Clinical and genomic data integrated with a novel property graph database schema from publicly available datasets and analyses based on The Cancer Genome Atlas lung cancer datasets augmented by with subgraphs patient-patient social network from similarity and correlation as well as individual based biological networks.
构建了一个非小细胞肺癌临床和基因组数据的新型图数据模型,具有两个目的:(1)提供一个适合于在 Neo4j 框架内或通过可通过现有 Neo4j API 进行交互的工具进行图分析的模型;(2)提供一个可扩展到其他癌症类型和其他数据集(例如来自电子健康记录和其他真实来源的数据)的基础模型。
临床和基因组数据与来自公开数据集的新型属性图数据库模式集成,并基于癌症基因组图谱肺癌数据集进行分析,其中还包括通过相似性和相关性以及基于个体的生物网络来自患者-患者社交网络的子图。