Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Brain Behav. 2022 Mar;12(3):e2484. doi: 10.1002/brb3.2484. Epub 2022 Feb 14.
The differences of functional connectivity (FC) and functional asymmetry between left and right mesial temporal lobe epilepsy with hippocampal sclerosis (LMTLE and RMTLE) have not been completely clarified yet. The purpose of the present study is to investigate the FC changes and the FC asymmetric patterns of MTLE, and to compare the differences in FC and functional asymmetry between LMTLE and RMTLE.
In total, 12 LMTLE, 11 RMTLE patients, and 23 healthy controls (HC) were included. Region of interest (ROI)-based analysis was used to evaluate FC. The right functional connectivity (rFC) and left functional connectivity (lFC) of each ROI were calculated. Asymmetry index (AI) was calculated based on the following formula: . Paired t-test and univariate analysis of variance were used to analyze FC asymmetry. Linear correlation analysis was performed between significant FC changes and lateralized ROIs and epilepsy onset age and duration.
LMTLE and RMTLE patients showed different patterns of alteration in FC and functional asymmetry when compared with controls. RMTLE presented more extensive FC abnormalities than LMTLE. Regions in ipsilateral temporal lobe presented as central regions of abnormalities in both patient groups. In addition, the asymmetric characteristics of FC were reduced in MTLE compared with HC, with even more pronounced reduction for RMTLE group. Meanwhile, ROIs presented FC AI differences among the three groups were mostly involving left temporal lobe (L_hippo, L_amyg, L_TP, L_aMTG, and L_pTFusC). No correlation was found between significant FC changes and lateralized ROIs and epilepsy onset age and duration.
The FC and asymmetric features of MTLE are altered and involve both the temporal lobe and extra-temporal lobe. Furthermore, the altered FC and asymmetric features were distinctly affected in LMTLE and RMTLE compared to controls.
左、右侧海马硬化性内侧颞叶癫痫（LMTLE 和 RMTLE）之间的功能连接（FC）和功能不对称性的差异尚未完全阐明。本研究旨在探讨 MTLE 的 FC 变化和 FC 不对称模式，并比较 LMTLE 和 RMTLE 之间 FC 和功能不对称性的差异。
共纳入 12 例 LMTLE 患者、11 例 RMTLE 患者和 23 例健康对照者（HC）。采用基于感兴趣区（ROI）的分析方法评估 FC。计算每个 ROI 的右功能连接（rFC）和左功能连接（lFC）。根据以下公式计算不对称指数（AI）： 。采用配对 t 检验和单因素方差分析比较 FC 不对称性。对显著的 FC 变化与偏侧化 ROI 及癫痫发病年龄和病程之间进行线性相关分析。
与对照组相比，LMTLE 和 RMTLE 患者的 FC 和功能不对称性表现出不同的变化模式。RMTLE 患者的 FC 异常比 LMTLE 患者更为广泛。在两组患者中，同侧颞叶区域呈现为异常的中心区域。此外，与 HC 相比，MTLE 的 FC 不对称特征减少，而 RMTLE 组更为明显。同时，三组间 FC AI 差异的 ROI 主要涉及左侧颞叶（L_hippo、L_amyg、L_TP、L_aMTG 和 L_pTFusC）。未发现显著 FC 变化与偏侧化 ROI 及癫痫发病年龄和病程之间存在相关性。
MTLE 的 FC 和不对称特征发生改变，涉及颞叶和颞外区域。此外，与对照组相比，LMTLE 和 RMTLE 患者的 FC 改变和不对称特征明显不同。
