Wu Jinlong, Wu Jun, Guo Ruimin, Chu Linkang, Li Jun, Zhang Sheng, Ren Hongwei
Department of Imaging Center, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Key Laboratory of Occupational Hazards and Identification, Wuhan University of Science and Technology, Wuhan, China.
Front Psychiatry. 2022 Aug 10;13:972939. doi: 10.3389/fpsyt.2022.972939. eCollection 2022.
We aimed to explore voxel-mirrored homotopic connectivity (VMHC) abnormalities between the two brain hemispheres in left temporal lobe epilepsy (lTLE) patients and to determine whether these alterations could be leveraged to guide lTLE diagnosis.
Fifty-eight lTLE patients and sixty healthy controls (HCs) matched in age, sex, and education level were recruited to receive resting state functional magnetic resonance imaging (rs-fMRI) scan. Then VHMC analyses of bilateral brain regions were conducted based on the results of these rs-fMRI scans. The resultant imaging data were further analyzed using support vector machine (SVM) methods.
Compared to HCs, patients with lTLE exhibited decreased VMHC values in the bilateral middle temporal gyrus (MTG) and middle cingulum gyrus (MCG), while no brain regions in these patients exhibited increased VMHC values. SVM analyses revealed the diagnostic accuracy of reduced bilateral MTG VMHC values to be 75.42% (89/118) when differentiating between lTLE patients and HCs, with respective sensitivity and specificity values of 74.14% (43/58) and 76.67% (46/60).
Patients with lTLE exhibit abnormal VMHC values corresponding to the impairment of functional coordination between homotopic regions of the brain. These altered MTG VMHC values may also offer value as a robust neuroimaging biomarker that can guide lTLE patient diagnosis.
我们旨在探究左侧颞叶癫痫（lTLE）患者两个脑半球之间的体素镜像同伦连接性（VMHC）异常，并确定这些改变是否可用于指导lTLE的诊断。
招募58例lTLE患者和60名年龄、性别及教育水平相匹配的健康对照者（HCs），进行静息态功能磁共振成像（rs-fMRI）扫描。然后根据这些rs-fMRI扫描结果对双侧脑区进行VMHC分析。对所得影像数据进一步采用支持向量机（SVM）方法进行分析。
与HCs相比，lTLE患者双侧颞中回（MTG）和扣带中回（MCG）的VMHC值降低，而这些患者的脑区中没有VMHC值升高的情况。SVM分析显示，在区分lTLE患者和HCs时，双侧MTG的VMHC值降低的诊断准确率为75.42%（89/118），敏感性和特异性分别为74.14%（43/58）和76.67%（46/60）。
lTLE患者表现出与脑同伦区域之间功能协调受损相对应的VMHC值异常。这些MTG的VMHC值改变也可能作为一种可靠的神经影像生物标志物，对lTLE患者的诊断具有指导价值。
