School of Public Health, North China University of Science and Technology, Tangshan, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Appl Physiol Nutr Metab. 2022 Mar;47(3):321-327. doi: 10.1139/apnm-2021-0078. Epub 2022 Feb 15.
The objective of this study was to explore the effects of fetal experience of famine on the onset of type 2 diabetes mellitus (T2DM) in adults. The analysis included 16 594 participants from the Kailuan Study who were free of diabetes at baseline (2006). According to the date of birth, the individuals born on October 1, 1962 - September 30, 1964, were divided into the non-exposed group (used as the reference group), individuals born on October 1, 1959 - September 30, 1961, were divided into the fetal exposure group, and the early childhood exposure group included those born on October 1, 1956 - September 30, 1958. The cumulative incidence of T2DM for each group was calculated and compared among the 3 groups, and the Cox regression model was used to analyze the effects of fetal famine experience on the risk of diabetes. During a median 10.27 years (170 358 person-years) (2006-2017), 3509 incident T2DM cases were identified, with a cumulative incidence rate of 19.46%. The cumulative incidences of T2DM in the non-exposed, fetal exposure, and early childhood exposure groups were 17.38%, 20.85%, and 20.65%, respectively ( < 0.01). After adjusting for confounding factors, the hazard ratio (HR) of T2DM in the fetal exposure group was 1.222 (95% confidence interval: 1.087-1.374, < 0.01), compared with the reference group. The association was modified by sex and hypertension (both interaction less than 0.05). Fetal famine exposure may increase the risk of developing T2DM in adults. This association was more pronounced among women and those with hypertension. The association was modified by sex and hypertension. Long follow-up time.
本研究旨在探讨胎儿期饥荒经历对成年人 2 型糖尿病（T2DM）发病的影响。该分析包括来自开滦研究的 16594 名参与者，他们在基线时（2006 年）无糖尿病。根据出生日期，将 1962 年 10 月 1 日至 1964 年 9 月 30 日出生的个体分为非暴露组（作为参照组），1959 年 10 月 1 日至 1961 年 9 月 30 日出生的个体分为胎儿暴露组，将幼儿暴露组包括 1956 年 10 月 1 日至 1958 年 9 月 30 日出生的个体。计算每组的 T2DM 累积发病率，并比较 3 组之间的差异，采用 Cox 回归模型分析胎儿期饥荒经历对糖尿病风险的影响。在中位随访时间 10.27 年（170358 人年）（2006-2017 年）期间，共确定 3509 例 T2DM 新发病例，累积发病率为 19.46%。非暴露组、胎儿暴露组和幼儿暴露组的 T2DM 累积发病率分别为 17.38%、20.85%和 20.65%（<0.01）。调整混杂因素后，与参照组相比，胎儿暴露组 T2DM 的风险比（HR）为 1.222（95%置信区间：1.087-1.374，<0.01）。该关联受到性别和高血压的影响（均交互作用<0.05）。胎儿期饥荒暴露可能会增加成年人发生 T2DM 的风险。这种关联在女性和高血压患者中更为明显。该关联受到性别和高血压的影响。随访时间长。
