Lieb J P, Babb T L
Epilepsia. 1986 May-Jun;27(3):294-300. doi: 10.1111/j.1528-1157.1986.tb03542.x.
The time required for hippocampal seizure activity to propagate to the contralateral hippocampal formation was evaluated in 57 patients with complex partial seizures and related to histological findings following temporal lobectomy. Interhemispheric propagation times were found to be significantly longer (greater than 20 s) in those patients diagnosed as having hippocampal sclerosis than in those patients without hippocampal sclerosis. Quantitative analysis of cell densities was made in 28 patients. Dentate fascia granule densities and hippocampal pyramidal cell densities were found to be lower in those patients with longer interhemispheric propagation times. However, this relationship was not observed when only patients with hippocampal sclerosis were considered. Thus, a tendency for hippocampal seizures to exhibit interhemispheric propagation times greater than 20 s is suggestive of underlying hippocampal sclerosis. However, information about interhemispheric propagation time does not appear useful for estimating the actual degree of cell loss within the sclerotic hippocampus. The association of longer interhemispheric propagation times with hippocampal sclerosis supports the hypothesis that direct commissural connections between the hippocampal formations in humans are either unimportant or missing.
在57例复杂部分性癫痫患者中评估了海马癫痫活动传播至对侧海马结构所需的时间，并将其与颞叶切除术后的组织学发现相关联。发现诊断为海马硬化的患者半球间传播时间明显更长（超过20秒），比没有海马硬化的患者更长。对28例患者进行了细胞密度的定量分析。发现半球间传播时间较长的患者齿状回颗粒密度和海马锥体细胞密度较低。然而，仅考虑海马硬化患者时未观察到这种关系。因此，海马癫痫发作半球间传播时间大于20秒的趋势提示潜在的海马硬化。然而，关于半球间传播时间的信息似乎对估计硬化海马内细胞丢失的实际程度没有用处。半球间传播时间较长与海马硬化的关联支持了这样的假设，即人类海马结构之间的直接连合连接要么不重要要么缺失。
