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[脱细胞异体神经移植治疗手部神经缺损:来自德国一家手外科中心的经验]

[Use of acellular allogeneic nerve transplants for nerve defects of the hand : Experience from a German hand surgery center].

作者信息

Liodaki Eirini, Kisch Tobias, Mailänder Peter, Stang Felix

机构信息

Klinik für Plastische Chirurgie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland.

出版信息

Unfallchirurgie (Heidelb). 2022 Nov;125(11):892-896. doi: 10.1007/s00113-022-01143-6. Epub 2022 Feb 15.

DOI:10.1007/s00113-022-01143-6
PMID:35166880
Abstract

Peripheral nerve injuries are often encountered in traumatological care. The aim of this manuscript is to provide initial data, experiences and performance reports from Germany in the implantation of acellular human nerve transplants in peripheral sensory nerve defects of the hand and to put these data in the context of a comprehensive review of the literature. Of the patients 4 (7 digital nerves) were examined 6 months postoperatively and 5 patients (6 digital nerves) were examined 1 year after the operation (3 were also at the 6‑month examination). All patients had a clinical improvement after nerve reconstruction (≥ S3 according to the classification of sensory recovery of the Medical Research Council modified by Mackinnon and Dellon). Disadvantages of our clinical study are the small number of patients, the inhomogeneity (primary and secondary nerve reconstruction) and the lack of comparison with other nerve reconstruction methods.

摘要

周围神经损伤在创伤治疗中经常遇到。本手稿的目的是提供来自德国的关于脱细胞人神经移植物植入手部周围感觉神经缺损的初步数据、经验和性能报告,并将这些数据置于对文献的全面综述背景下。术后6个月对4例患者(7条指神经)进行了检查,术后1年对5例患者(6条指神经)进行了检查(其中3例患者在术后6个月时也接受了检查)。所有患者在神经重建后临床症状均有改善(根据麦金农和德龙修改的医学研究理事会感觉恢复分类标准,≥S3)。我们临床研究的缺点是患者数量少、存在异质性(一期和二期神经重建)以及缺乏与其他神经重建方法的比较。

相似文献

1
[Use of acellular allogeneic nerve transplants for nerve defects of the hand : Experience from a German hand surgery center].[脱细胞异体神经移植治疗手部神经缺损:来自德国一家手外科中心的经验]
Unfallchirurgie (Heidelb). 2022 Nov;125(11):892-896. doi: 10.1007/s00113-022-01143-6. Epub 2022 Feb 15.
2
Analysis of human acellular nerve allograft reconstruction of 64 injured nerves in the hand and upper extremity: a 3 year follow-up study.64例手部及上肢损伤神经的人脱细胞神经同种异体移植重建分析:一项3年随访研究
J Tissue Eng Regen Med. 2017 Aug;11(8):2314-2322. doi: 10.1002/term.2130. Epub 2016 Apr 21.
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[Applied methods instead of autologous nerve transplantation in the reconstruction of nerve injuries on the hand].[手部神经损伤重建中应用的方法而非自体神经移植]
Orv Hetil. 2017 Jul;158(30):1163-1167. doi: 10.1556/650.2017.30813.
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One-stage human acellular nerve allograft reconstruction for digital nerve defects.
Neural Regen Res. 2015 Jan;10(1):95-8. doi: 10.4103/1673-5374.150712.
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[Clinical safety about repairing the peripheral nerve defects with chemically extracted acellular nerve allograft].
Zhonghua Wai Ke Za Zhi. 2012 Jan 1;50(1):74-6.
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Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Aug;26(8):993-1000.
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Peripheral nerve regeneration and electrophysiological recovery with CIP-treated allogeneic acellular nerves.用 CIP 处理的同种异体去细胞神经促进周围神经再生和电生理恢复。
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本文引用的文献

1
A Retrospective Case Series Reporting the Outcomes of Avance Nerve Allografts in the Treatment of Peripheral Nerve Injuries.回顾性病例系列报告 Avance 异体神经移植物治疗周围神经损伤的结果。
Plast Reconstr Surg. 2020 Feb;145(2):368e-381e. doi: 10.1097/PRS.0000000000006485.
2
Recovery of Motor Function after Mixed and Motor Nerve Repair with Processed Nerve Allograft.使用处理过的同种异体神经移植进行混合神经和运动神经修复后运动功能的恢复
Plast Reconstr Surg Glob Open. 2019 Mar 13;7(3):e2163. doi: 10.1097/GOX.0000000000002163. eCollection 2019 Mar.
3
The normal sensibility of the hand declines with age--a proclamation for the use of delta two-point discrimination values for sensibility assessment after nerve reconstruction.
手部的正常感觉会随着年龄增长而下降——这是在神经重建后使用两点辨别觉差值进行感觉评估的一个依据。
J Peripher Nerv Syst. 2014 Sep;19(3):197-204. doi: 10.1111/jns.12085.
4
[Nerve injuries and posttraumatic therapy].[神经损伤与创伤后治疗]
Unfallchirurg. 2014 Jun;117(6):539-55; quiz 556. doi: 10.1007/s00113-014-2574-7.
5
Sensory recovery following decellularized nerve allograft transplantation for digital nerve repair.脱细胞异体神经移植修复指神经后的感觉恢复
J Plast Surg Hand Surg. 2013 Dec;47(6):451-3. doi: 10.3109/2000656X.2013.778862. Epub 2013 Jul 15.
6
Return of motor function after segmental nerve loss in a rat model: comparison of autogenous nerve graft, collagen conduit, and processed allograft (AxoGen).大鼠模型中节段性神经缺失后的运动功能恢复:自体神经移植、胶原导管和加工同种异体移植物(AxoGen)的比较。
J Bone Joint Surg Am. 2012 Mar 7;94(5):410-7. doi: 10.2106/JBJS.K.00253.
7
Processed nerve allografts for peripheral nerve reconstruction: a multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions.处理过的同种异体神经移植物在外周神经重建中的应用:一项多中心研究,涉及感觉神经、混合神经和运动神经重建中的利用和结果。
Microsurgery. 2012 Jan;32(1):1-14. doi: 10.1002/micr.20975. Epub 2011 Nov 28.
8
Multichanneled collagen conduits for peripheral nerve regeneration: design, fabrication, and characterization.多通道胶原导管用于周围神经再生:设计、制备和特性研究。
Tissue Eng Part C Methods. 2010 Dec;16(6):1585-96. doi: 10.1089/ten.TEC.2010.0152. Epub 2010 Jul 13.
9
Processed allografts and type I collagen conduits for repair of peripheral nerve gaps.用于修复周围神经缺损的处理过的同种异体移植物和I型胶原导管。
Muscle Nerve. 2009 Jun;39(6):787-99. doi: 10.1002/mus.21220.