Nielsen H, Bonde J
Eur J Respir Dis. 1986 Mar;68(3):200-6.
Since mononuclear phagocytes are crucial in resisting microbial challenge in the lung, selected functions of blood monocytes were studied in 27 patients with chronic bronchitis (19 with hypersecretory symptoms and many acute infectious exacerbations and eight with obstructive symptoms without recurrent infections), and compared with 82 healthy controls. While monocytes from patients with solely obstructive symptoms had a normal migratory function, both spontaneous and chemotactic migration were depressed in the patients with hypersecretory symptoms. Phagocytic activity of the blood monocytes was equally depressed in both subgroups. Intracellular killing of Candida albicans was normal in all patients when compared with smoking control subjects. Chemotactic responsiveness was thus decreased only in patients with hypersecretory symptoms, suggesting that a defect in monocyte migration in these patients might contribute to the high incidence of acute bronchial exacerbations.
由于单核吞噬细胞在抵抗肺部微生物感染方面至关重要，我们对27例慢性支气管炎患者（19例有分泌亢进症状且伴有多次急性感染加重，8例有阻塞性症状但无反复感染）的血液单核细胞的特定功能进行了研究，并与82名健康对照者进行了比较。虽然仅有阻塞性症状患者的单核细胞具有正常的迁移功能，但分泌亢进症状患者的自发迁移和趋化性迁移均受到抑制。两个亚组中血液单核细胞的吞噬活性均同样受到抑制。与吸烟对照者相比，所有患者对白色念珠菌的细胞内杀伤功能均正常。因此，只有分泌亢进症状患者的趋化反应性降低，这表明这些患者单核细胞迁移缺陷可能导致急性支气管加重的高发生率。
