Gardner I D, Lawton J W
J Reticuloendothel Soc. 1982 Dec;32(6):443-8.
Human monocytes were separated from peripheral blood of 22 normal healthy adults and incubated with Hsw1N1 influenza virus or diluted allantoic fluid. The treated monocyte populations were tested for five parameters of monocyte function. Influenza infection markedly inhibited the monocyte chemotactic response and the killing of Candida albicans; infection also depressed phagocytosis, slightly reduced spreading, but did not affect adhesion to glass. These results suggest that influenza virus may also have an inhibitory effect on monocyte function in vivo and help to explain the increased susceptibility to secondary bacterial infection and the general immunosuppression seen in influenza infection.
从22名正常健康成年人的外周血中分离出人类单核细胞，并将其与Hsw1N1流感病毒或稀释的尿囊液一起孵育。对经过处理的单核细胞群体进行单核细胞功能的五个参数检测。流感感染显著抑制单核细胞趋化反应和白色念珠菌的杀伤；感染还会抑制吞噬作用，略微降低铺展能力，但不影响对玻璃的黏附。这些结果表明，流感病毒可能也会对体内单核细胞功能产生抑制作用，并有助于解释流感感染中继发细菌感染易感性增加和普遍免疫抑制的现象。
