Department of Ophthalmology, Walter Reed National Military Medical Center, Bethesda, MD, United States.
Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, IL, United States.
Ocul Surf. 2022 Apr;24:67-73. doi: 10.1016/j.jtos.2022.02.001. Epub 2022 Feb 12.
Ocular surface disease (OSD) in the setting of thyroid eye disease (TED) is traditionally thought of as a natural consequence of anatomical changes such as proptosis and corneal exposure. However, a growing body of research suggests that ocular surface inflammation and multi-factorial changes to the homeostasis of the ocular surface contribute substantially to the OSD seen in TED patients. In this paper we review the existing literature which highlights the work and existing theories underlying this new paradigm shift.
甲状腺相关眼病(TED)患者的眼表疾病(OSD)通常被认为是眼球突出和角膜暴露等解剖结构改变的自然结果。然而,越来越多的研究表明,眼表炎症和眼表稳态的多因素变化对 TED 患者的 OSD 有重要影响。本文综述了现有文献,重点介绍了这一新范式转变背后的工作和现有理论。