Biomaterials Niche Group, School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang, Malaysia.
Department of Inorganic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
J Mech Behav Biomed Mater. 2022 Apr;128:105122. doi: 10.1016/j.jmbbm.2022.105122. Epub 2022 Feb 7.
Dense iron-doped akermanite ceramics with 0.3, 0.6 and 0.9 mol% of Fe were synthesized via high-speed planetary ball milling and subsequently subjected to sintering at 1200 and 1250 °C. The aim of the current work was to investigate the effect of trivalent iron (Fe) in tuning the physicomechanical and in vitro biological properties of akermanite. The incorporation of Fe into akermanite host and sintering at a high temperature of 1200 °C resulted in a synergistic effect in enhancing the sinterability and densification of akermanite ceramics. Although varying the Fe content, it was found that similar densification and mechanical properties (i.e., diametral tensile strength, Vickers microhardness and fracture toughness) were observed for the doped ceramics at 1250 °C, indicating that this newly developed formulation is temperature-dependent. Fe-doped akermanite ceramics revealed greater in vitro bioactivity as compared to undoped akermanite, demonstrated by better coverage of needle-like apatite precipitates after 21 days of immersion in simulated body fluid. Additionally, Rat-1 cells cultured in direct contact with Fe-doped akermanite ceramics showed almost double levels of cell proliferation than their undoped counterpart on both 3 and 7 days of culture. Our finding suggests that 0.9Fe-AK ceramic is a suitable formulation to be considered for future bone substitute material as it provides sufficient mechanical strength as well as good bioactivity and the ability to encourage cell proliferation.
通过高速行星球磨合成了 0.3、0.6 和 0.9 mol% Fe 的致密铁掺杂镁黄长石陶瓷，然后在 1200 和 1250°C 下进行烧结。本工作的目的是研究三价铁 (Fe) 对调谐镁黄长石的物理力学和体外生物学性能的影响。Fe 掺入镁黄长石宿主并在 1200°C 的高温下烧结导致烧结和致密化协同效应，增强了镁黄长石陶瓷的烧结和致密化。尽管 Fe 含量不同，但在 1250°C 下发现掺杂陶瓷的致密化和机械性能（即，直径拉伸强度、维氏显微硬度和断裂韧性）相似，表明这种新开发的配方是温度依赖性的。与未掺杂的镁黄长石相比，Fe 掺杂的镁黄长石陶瓷表现出更高的体外生物活性，在模拟体液中浸泡 21 天后，针状磷灰石沉淀物的覆盖更好。此外，在与 Fe 掺杂的镁黄长石陶瓷直接接触培养的 Rat-1 细胞在培养 3 天和 7 天的细胞增殖水平比未掺杂的细胞高出近两倍。我们的发现表明，0.9Fe-AK 陶瓷是一种合适的配方，可考虑用于未来的骨替代材料，因为它提供了足够的机械强度以及良好的生物活性和促进细胞增殖的能力。
