Biomaterials Research Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia; Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Darul Ehsan, Malaysia.
Biomaterials Research Group, School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia.
J Mech Behav Biomed Mater. 2021 Apr;116:104379. doi: 10.1016/j.jmbbm.2021.104379. Epub 2021 Feb 4.
Despite the excellent in vitro and in vivo performance of akermanite ceramic, its poor toughness and strength limit the biomedical application, particularly under load. Herein, the incorporation of strontium enhanced the physicomechanical properties of akermanite and this is ascribed to the decrease in grain size and better sinterability. To investigate the biological performance, the bone-cell interaction with sintered pellets was assessed by in vitro biocompatibility with human fetal osteoblast cell (hFOB). The cell viability using MTT assay revealed that the CaSrMgSiO pellets with finer grain size provided better interaction between the cells compared to the unsubstituted counterpart with larger grain size. Our findings highlighted that the synergistic effect of controlled degradation rate and release of Sr into the medium enhanced the in vitro biological properties of akermanite-based materials.
尽管镁硅钙石陶瓷具有优异的体外和体内性能，但它的韧性和强度较差，限制了其在生物医学领域的应用，尤其是在受力的情况下。在此，锶的掺入增强了镁硅钙石的物理力学性能，这归因于晶粒尺寸的减小和更好的烧结性能。为了研究生物性能，通过与人体胎骨成纤维细胞（hFOB）的体外生物相容性来评估烧结颗粒的骨细胞相互作用。MTT 检测法的细胞活力表明，与晶粒尺寸较大的未取代物相比，晶粒尺寸较小的 CaSrMgSiO 颗粒提供了更好的细胞相互作用。我们的研究结果表明，控制降解率和 Sr 释放到介质中的协同作用增强了基于镁硅钙石的材料的体外生物性能。
