I.M. Sechenov First Moscow Medical University (Sechenov University), Moscow.
Kardiologiia. 2022 Jan 31;62(1):65-71. doi: 10.18087/cardio.2022.1.n1952.
Aim To evaluate the effect of perindopril on the endothelial function and levels of endothelial dysfunction markers in groups of patients with heart failure with preserved (HFpEF) and mid-range (intermediate) left ventricular ejection fraction (HFmrEF).Material and methods 40 patients with HFpEF (n=20) and HFmrEF (n=20) were evaluated. At baseline, parameters of the morpho-functional state of large blood vessels and of microvessels were evaluated with photoplethysmography, and levels of E-selectin and endothelin-1 (ET-1) were measured. The patients were prescribed perindopril, and after 12 months of treatment, photoplethysmographic parameters and endothelial dysfunction markers were determined again.Results After 12 months of the perindopril treatment, improvements in the endothelial function of both large blood vessels and microvessels were noted. The phase shift increased from 10.1 to 10.9 ms in the HFpEF group (р=0.001) and from 8.35 to 9.65 ms in the HFmrEF group (р=0.002). Furthermore, the occlusion index increased from 1.45 to 1.75 in patients with HFpEF (р=0.004) and from 1.5 to 1.75 in patients with HFmrEF (р=0.010). The Е-selectin concentration decreased in both groups, from 57.25 to 42.4 ng/ml (р=0.00008) and from 40.5 to 35.7 ng/ml (р=0.010) in patients with HFpEF and HFmrEF, respectively. The ET-1 concentration decreased from pg/ml (р=0.010) in patients with HFpEF whereas in patients with HFmrEF, there was no significant change in the ET-1 concentration after 12 months of the perindopril treatment.Conclusion At 12 months, the endothelial function improved and E-selectin and ET-1 levels decreased in patients with HFpEF and HFmrEF.
评估培哚普利对射血分数保留心力衰竭（HFpEF）和中间范围（中间）左心室射血分数（HFmrEF）患者组内皮功能和内皮功能障碍标志物水平的影响。
评估了 40 名 HFpEF（n=20）和 HFmrEF（n=20）患者。在基线时，使用光体积描记法评估大血管和微血管的形态功能状态参数，并测量 E-选择素和内皮素-1（ET-1）水平。给患者开了培哚普利，治疗 12 个月后，再次测定光体积描记法参数和内皮功能障碍标志物。
培哚普利治疗 12 个月后，大血管和微血管的内皮功能均得到改善。HFpEF 组的相移从 10.1 增加到 10.9ms（р=0.001），HFmrEF 组从 8.35 增加到 9.65ms（р=0.002）。此外，HFpEF 患者的闭塞指数从 1.45 增加到 1.75（р=0.004），HFmrEF 患者从 1.5 增加到 1.75（р=0.010）。两组的 E-选择素浓度均降低，HFpEF 组从 57.25 降至 42.4ng/ml（р=0.00008），HFmrEF 组从 40.5 降至 35.7ng/ml（р=0.010）。HFpEF 患者的 ET-1 浓度从 pg/ml 降低（р=0.010），而 HFmrEF 患者在培哚普利治疗 12 个月后，ET-1 浓度没有显著变化。
在 12 个月时，HFpEF 和 HFmrEF 患者的内皮功能改善，E-选择素和 ET-1 水平降低。
