Division of Infectious Diseases, Department of Pediatrics, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104-4399, USA.
Division of Infectious Diseases, Department of Pediatrics, Washington University, 425 S. Euclid Avenue, McDonnell Pediatric Research Building, #5105, St Louis, MO 63106, USA.
Infect Dis Clin North Am. 2022 Mar;36(1):125-146. doi: 10.1016/j.idc.2021.11.004.
Recipients of solid organ and hematopoietic stem cell transplantation undergo substantial immune suppression, placing them at risk for opportunistic viral infection. Few randomized controlled trials have been dedicated to the treatment of viral infections in children, and current practices are extrapolated from data generated from adult patients. Here we discuss the prevention and treatment of viral infections using available antiviral drugs, as well as novel agents that may provide benefit to pediatric patients in the future.
实体器官和造血干细胞移植受者接受大量免疫抑制治疗，使他们面临机会性病毒感染的风险。很少有随机对照试验专门针对儿童病毒感染的治疗，目前的治疗方法是从成人患者的数据中推断出来的。在这里，我们讨论了使用现有抗病毒药物预防和治疗病毒感染的问题，以及未来可能对儿科患者有益的新型药物。
