溶菌酶对细菌细胞壁的体内降解作用。
In vivo degradation of bacterial cell wall by the muralytic enzyme mutanolysin.
作者信息
Janusz M J, Esser R E, Schwab J H
出版信息
Infect Immun. 1986 May;52(2):459-67. doi: 10.1128/iai.52.2.459-467.1986.
Abstract
The muralytic enzyme mutanolysin can act in vivo to eliminate chronic erosive arthritis induced in rats by polymers of peptidoglycan-polysaccharide isolated from group A streptococci (PG-APS). The amounts of PG-APS in the livers and spleens of rats treated with mutanolysin were significantly reduced compared with the amounts in control rats treated with phosphate-buffered saline. However, the amounts of PG-APS in the limbs of mutanolysin- and phosphate-buffered saline-treated rats were comparable. PG-APS polymers extracted from the livers, spleens, and limbs of mutanolysin-treated rats were extensively degraded, whereas PG-APS extracted from phosphate-buffered saline-treated rats had a high molecular weight. We propose that mutanolysin abrogates arthritis in rats by degrading PG-APS polymers to a size which is no longer able to induce chronic erosive arthritis, even though the polymers are still present in the limbs.
摘要
溶菌酶（mutanolysin）这种溶壁酶可在体内发挥作用，消除由从A组链球菌分离出的肽聚糖 - 多糖聚合物（PG - APS）诱导大鼠产生的慢性侵蚀性关节炎。与用磷酸盐缓冲盐水处理的对照大鼠相比，用溶菌酶处理的大鼠肝脏和脾脏中PG - APS的量显著减少。然而，用溶菌酶和磷酸盐缓冲盐水处理的大鼠四肢中PG - APS的量相当。从用溶菌酶处理的大鼠的肝脏、脾脏和四肢中提取的PG - APS聚合物被广泛降解，而从用磷酸盐缓冲盐水处理的大鼠中提取的PG - APS具有高分子量。我们认为，溶菌酶通过将PG - APS聚合物降解至不再能够诱导慢性侵蚀性关节炎的大小来消除大鼠的关节炎，尽管聚合物仍存在于四肢中。
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本文引用的文献
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