Santos Miguel, Pires Tatiana, Rodrigues Ana, Bandeira Adriana, Albuquerque Ana, Santos Flávia, Magalhães Miriam, Banza Maria Jesus
Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal.
Eur J Case Rep Intern Med. 2022 Jan 27;9(1):003107. doi: 10.12890/2022_003107. eCollection 2022.
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extra-nodal non-Hodgkin lymphoma (NHL). It must be confined to the brain, eyes, spinal cord or leptomeninges without systemic involvement at the time of diagnosis. Disease confined to the cerebrospinal fluid (CSF) is a rare form of presentation and poses a particular diagnostic challenge. We present the case of an 82-year-old man admitted to hospital because of an acute confusional state, later revealed to be due to PCNSL with exclusive leptomeningeal involvement. The diagnostic process was further impaired (or, perhaps, aided?) by the onset of a COVID-19 outbreak on the ward.
Primary central nervous system lymphoma is a rare and aggressive form of non-Hodgkin lymphoma.Exclusive involvement of the cerebrospinal fluid (CSF) is a rare form of presentation of PCNSL.The diagnosis is usually histopathological but, in the absence of a solid lesion that can be biopsied, CSF cytology and flow cytometry may be sufficient for a definitive diagnosis.
原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见的侵袭性结外非霍奇金淋巴瘤（NHL）。在诊断时，它必须局限于脑、眼、脊髓或软脑膜，无全身受累。局限于脑脊液（CSF）的疾病是一种罕见的表现形式，带来了特殊的诊断挑战。我们报告一例82岁男性因急性意识模糊状态入院，后来发现是由仅累及软脑膜的PCNSL所致。病房内COVID-19疫情的爆发进一步阻碍（或者，也许是有助于？）了诊断过程。
原发性中枢神经系统淋巴瘤是一种罕见的侵袭性非霍奇金淋巴瘤形式。脑脊液（CSF）单独受累是PCNSL的一种罕见表现形式。诊断通常为组织病理学诊断，但在没有可活检的实体病变时，脑脊液细胞学检查和流式细胞术可能足以做出明确诊断。
