Department of Specialty Medicine, Midwestern University College of Veterinary Medicine, Glendale, Arizona, USA.
Department of Pathology and Population Medicine, Midwestern University College of Veterinary Medicine, Glendale, Arizona, USA.
J Vet Intern Med. 2022 Mar;36(2):565-575. doi: 10.1111/jvim.16384. Epub 2022 Feb 15.
Gallbladder mucocele (GBM) is a common biliary disorder in dogs that can be categorized into 6 types, but the value of this classification scheme remains unknown. Cholecystectomy is associated with high death rates and warrants additional interrogation.
Investigate the clinical value of ultrasonographic diagnosis of type of GBM and identify prognostic factors in dogs with GBM undergoing cholecystectomy.
Two hundred sixteen dogs.
Retrospective cohort study. Dogs with GBM diagnosed from 2014 to 2019 at 6 veterinary referral hospitals in Asia. Ultrasonogram images were reviewed and a GBM type (ie, types I-VI) assigned.
Dogs with GBM type V as compared to I (OR, 8.6; 95% CI, 2.6-27.8; P < .001) and III (OR, 10.0; 95% CI, 2.5-40.8; P = .001), and dogs with type VI compared to I (OR, 10.5; 95% CI, 1.8-61.2; P = .009) and III (OR, 12.3; 95% CI, 1.8-83.9; P = .01) were more likely to exhibit signs of biliary tract disease. Independent predictors of death after cholecystectomy included age (OR, 2.81; 95% CI, 1.41-5.59; P = .003) and intraoperative systolic blood pressure (SBP) nadir. There was an interaction between SBP nadir and gallbladder rupture; SBP nadir in dogs with (OR, 0.92; 95% CI, 0.89-0.94; P < .001) and without (OR, 0.88; 95% CI, 0.82-0.93; P < .001) gallbladder rupture.
Increasing developmental stage of GBM could be associated with an increased likelihood of biliary tract related clinical signs. Nadir SBP deserves further investigation as a prognostic or potentially modifiable variable, particularly in the presence of gallbladder rupture.
胆囊黏液囊肿（GBM）是犬中常见的胆道疾病，可分为 6 型，但该分类方案的价值尚不清楚。胆囊切除术与高死亡率相关，需要进一步探讨。
研究超声诊断 GBM 类型的临床价值，并确定行胆囊切除术的 GBM 犬的预后因素。
216 只狗。
回顾性队列研究。2014 年至 2019 年，亚洲 6 家兽医转诊医院诊断为 GBM 的犬。回顾性超声图像并分配 GBM 类型（即，类型 I-VI）。
与 I 型相比，GBM 类型 V（OR，8.6；95%CI，2.6-27.8；P<0.001）和 III 型（OR，10.0；95%CI，2.5-40.8；P=0.001），与 I 型（OR，10.5；95%CI，1.8-61.2；P=0.009）和 III 型（OR，12.3；95%CI，1.8-83.9；P=0.01）相比，VI 型犬更有可能出现胆道疾病的迹象。胆囊切除术后死亡的独立预测因素包括年龄（OR，2.81；95%CI，1.41-5.59；P=0.003）和术中收缩压（SBP）最低值。SBP 最低值与胆囊破裂之间存在交互作用；有（OR，0.92；95%CI，0.89-0.94；P<0.001）和无（OR，0.88；95%CI，0.82-0.93；P<0.001）胆囊破裂的犬 SBP 最低值。
GBM 的发育阶段增加可能与胆道相关临床症状的可能性增加相关。SBP 最低值值得进一步研究，作为预后或潜在可改变的变量，特别是在存在胆囊破裂的情况下。
