Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
J Vet Intern Med. 2021 Mar;35(2):878-886. doi: 10.1111/jvim.16051. Epub 2021 Feb 6.
Proteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown.
Determine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinuria.
Twenty-five dogs with mucocele formation and 25 breed and age-matched control dogs from a prior study.
Retrospective case control study. Proteinuria defined by calculated urine dipstick protein concentration (mg/mL) to urine specific gravity (USG) ratio. Clinicopathologic findings, postcosyntropin cortisol concentration, thyroid function profile, and illness severity score were recorded.
Median urine dipstick protein concentration to USG ratio and number of dogs having a ratio ≥1.5 were significantly higher for dogs with mucocele formation compared to control dogs. Proteinuria was not significantly associated with CBC or serum biochemistry profile abnormalities but increased in relation to severity of illness.
Gallbladder mucocele formation is significantly associated with proteinuria in dogs. Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients.
蛋白尿是犬类发病率和死亡率的独立危险因素。目前尚不清楚蛋白尿与胆囊黏液囊肿形成之间的关系。
确定胆囊黏液囊肿形成或临床病理合并症是否与蛋白尿有关。
25 只患有黏液囊肿的犬和 25 只来自先前研究的具有相同品种和年龄的对照犬。
回顾性病例对照研究。通过计算尿试纸蛋白浓度（mg/mL）与尿比重（USG）的比值来定义蛋白尿。记录临床病理发现、促皮质素后皮质醇浓度、甲状腺功能谱和疾病严重程度评分。
与对照组相比，患有黏液囊肿的犬的尿试纸蛋白浓度与 USG 比值的中位数和出现比值≥1.5 的犬的数量显著更高。蛋白尿与全血细胞计数或血清生化特征异常无显著相关性，但与疾病严重程度相关。
胆囊黏液囊肿形成与犬的蛋白尿显著相关。在患有黏液囊肿的犬中诊断和治疗蛋白尿可能会最大限度地减少这些患者的长期肾脏发病率。
