Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China.
Center for BioDelivery Sciences, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Rd, Shanghai, 200240, P. R. China.
Chem Soc Rev. 2022 Mar 7;51(5):1766-1794. doi: 10.1039/d1cs00786f.
Adoptive immunotherapies based on the transfer of functional immune cells hold great promise in treating a wide range of malignant diseases, especially cancers, autoimmune diseases, and infectious diseases. However, manufacturing issues and biological barriers lead to the insufficient population of target-selective effector cells at diseased sites after adoptive transfer, hindering effective clinical translation. The convergence of immunology, cellular biology, and materials science lays a foundation for developing biomaterial-based engineering platforms to overcome these challenges. Biomaterials can be rationally designed to improve immune cell expansion, expedite functional engineering, facilitate protective delivery of immune cells , and navigate the infused cells . Herein, this review presents a comprehensive summary of the latest progress in biomaterial-based strategies to enhance the efficacy of adoptive cell therapy, focusing on function-specific biomaterial design, and also discusses the challenges and prospects of this field.
基于功能免疫细胞转移的过继免疫疗法在治疗多种恶性疾病方面具有巨大的应用前景，尤其是癌症、自身免疫性疾病和传染病。然而，制造问题和生物屏障导致过继转移后，在病变部位靶向选择性效应细胞的数量不足，从而阻碍了有效的临床转化。免疫学、细胞生物学和材料科学的融合为开发基于生物材料的工程平台以克服这些挑战奠定了基础。可以对生物材料进行合理设计，以提高免疫细胞的扩增、加快功能工程、促进免疫细胞的保护性递送，并引导输注细胞。本文全面总结了基于生物材料的策略在提高过继细胞治疗效果方面的最新进展，重点介绍了功能特异性生物材料设计，并讨论了该领域的挑战和前景。
