State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Department of Ophthalmology and Otolaryngology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
Nanoscale. 2022 Mar 7;14(9):3306-3323. doi: 10.1039/d1nr08394e.
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. Given its inconspicuous and atypical early symptoms and hidden location, most patients have already reached the terminal stage before diagnosis. At present, the diagnosis of PDAC mainly depends on serological and imaging examinations. However, serum tests cannot identify specific tumor locations and each imaging technology has its own defects, bringing great challenges to the early diagnosis of PDAC. Therefore, it is of great significance to find new strategies for the early and accurate diagnosis of PDAC. In recent years, a magneto-optical nanoplatform integrating near infrared fluorescence, photoacoustic, magnetic resonance imaging, . has attracted widespread attention, giving full play to the complementary advantages of each imaging modality. Herein, we summarize the recent advances of imaging modalities in the diagnosis of pancreatic cancer, and then discuss in detail the construction and modification of magneto or/and optical probes for multimodal imaging, and advances in early diagnosis using the combination of various imaging modalities, which can provide potential tools for the early diagnosis or even intraoperative navigation and post-treatment follow-up of PDAC patients.
胰腺导管腺癌 (PDAC) 是最常见的胰腺癌类型。由于其不明显和非典型的早期症状以及隐藏的位置，大多数患者在诊断前已经处于晚期。目前，PDAC 的诊断主要依赖于血清学和影像学检查。然而，血清检测无法识别特定的肿瘤位置，每种成像技术都有其自身的缺陷，给 PDAC 的早期诊断带来了巨大挑战。因此，寻找 PDAC 早期和准确诊断的新策略具有重要意义。近年来，一种集近红外荧光、光声、磁共振成像于一体的磁光纳米平台 . 引起了广泛关注，充分发挥了每种成像方式的互补优势。本文总结了影像学在胰腺癌诊断中的最新进展，然后详细讨论了用于多模态成像的磁学或/和光学探针的构建和修饰，以及各种成像方式联合应用于早期诊断的进展，为 PDAC 患者的早期诊断甚至术中导航和治疗后随访提供了潜在的工具。
