Liu Yaqi, Xu Huachun, Bai Shihao, Chen Tianxiang, Ma Xuehua, Lin Jie, Sun Linglin, Gao Changyong, Wu Aiguo, Li Qiang
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials at Ningbo Cixi Institute of Biomedical Engineering, Institute of Biomedical Engineering at Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Regen Biomater. 2025 Jun 11;12:rbaf054. doi: 10.1093/rb/rbaf054. eCollection 2025.
Pancreatic cancer is one of the most lethal malignancies, largely due to the limitations of current imaging technologies and treatment strategies, which hinder early diagnosis and effective disease management. Achieving precise theranostics for pancreatic cancer has become a priority, and recent advances have focused on the development of novel nanomaterials with enhanced imaging capabilities and therapeutic functionalities. These nanomaterials, through surface modifications, can significantly improve the targeting and precision of both diagnostic and therapeutic applications. Recent progress in nanomaterial design has led to the creation of multifunctional platforms that not only enhance imaging but also improve therapeutic efficacy. These innovations have spurred significant interest in the application of nanomaterials for pancreatic cancer theranostics. In this review, we highlight recent developments in the use of nanomaterials for diagnostic imaging and precision therapy in pancreatic cancer. Various applications, including magnetic, optical, acoustic and radiological imaging, as well as therapeutic strategies such as chemodynamic therapy, light-based therapy, sonodynamic therapy and gene therapy, are discussed. Despite the promising potential of these nanomaterials, several challenges remain. These include optimizing targeting mechanisms, enhancing nanomaterial stability , overcoming biological barriers and ensuring safe and effective translation to clinical settings. Addressing these challenges will require further research and innovation. With sustained efforts, nanomaterial-assisted diagnostics and therapeutics have the potential to revolutionize the management of pancreatic cancer, ultimately improving early detection and treatment outcomes. Continued progress in this field could significantly enhance the overall prognosis for pancreatic cancer patients, making it a more treatable disease in the future.
胰腺癌是最致命的恶性肿瘤之一，这主要归因于当前成像技术和治疗策略的局限性，这些局限性阻碍了早期诊断和有效的疾病管理。实现胰腺癌的精确诊疗已成为当务之急，最近的进展集中在开发具有增强成像能力和治疗功能的新型纳米材料上。这些纳米材料通过表面修饰，可以显著提高诊断和治疗应用的靶向性和精确性。纳米材料设计的最新进展导致了多功能平台的创建，这些平台不仅增强了成像效果，还提高了治疗效果。这些创新激发了人们对纳米材料在胰腺癌诊疗中应用的浓厚兴趣。在这篇综述中，我们重点介绍了纳米材料在胰腺癌诊断成像和精确治疗方面的最新进展。讨论了各种应用，包括磁性、光学、声学和放射成像，以及化学动力学疗法、光基疗法、声动力疗法和基因疗法等治疗策略。尽管这些纳米材料具有广阔的应用前景，但仍存在一些挑战。这些挑战包括优化靶向机制、提高纳米材料稳定性、克服生物屏障以及确保安全有效地转化到临床应用中。应对这些挑战需要进一步的研究和创新。通过持续努力，纳米材料辅助的诊断和治疗有可能彻底改变胰腺癌的管理方式，最终改善早期检测和治疗效果。该领域的持续进展有望显著提高胰腺癌患者的总体预后，使未来胰腺癌成为一种更可治疗的疾病。
