Atum Mahmut, Kocayiğit İbrahim, Sahinkuş Salih, Coşkun Şule Bahadır, Çelik Erkan
Department of Ophthalmology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Arq Bras Oftalmol. 2022 Feb 14;85(6):578-583. doi: 10.5935/0004-2749.20220085. eCollection 2022.
To investigate whether pseudoexfoliation syndrome affects arterial stiffness by using cardio-ankle vascular index measurement.
This cross-sectional case-control study included 55 patients with pseudoexfoliation syndrome and 106 age- and gender-matched healthy control subjects. All subjects underwent a complete ophthalmic exa mination of both eyes and cardio-ankle vascular index measu rements. Echocardiographic and body mass index measurements were performed in all patients, and the results were recorded. A binary regression model was used to determine the relationship between cardio-ankle vascular index and pseudoexfoliation.
There were no significant differences between the pseudoexfoliation and control groups in baseline clinical and demographic characteristics, echocardiographic measurements of left ventricular ejection fraction, and body mass index. The mean cardio-ankle vascular index value was significantly higher in the pseudoexfoliation group than in the controls (9.47 ± 1.23 vs. 8.33 ± 1.50, p<0.001). Intraocular pressure was significantly higher in the pseudoexfoliation group than in the controls (18.31 ± 1.78 vs. 15.24 ± 2.42 mm Hg, p<0.05). Although the logistic regression analysis showed that mean cardio-ankle vascular index and IOP values were positively associated with pseudoexfoliation syndrome (Odds ratios (OR) = 1.973, 95% CI, 1.051-3.706, p=0.035; OR=3.322, 95% CI = 2.000-5.520, p<0.001, respectively), the Pearson correlation analysis revealed a borderline significant positive correlation between age and mean cardio-ankle vascular index and a significant positive correlation between dyslipidemia and intraocular pressure and mean cardio-ankle vascular index (r=0.265, p=0.050; r=0.337, p=0.012; r=0.433, p=0.001, respectively).
Our findings demonstrated that cardio-ankle vascular index values increased in patients with pseudoexfoliation syndrome.
通过测量心踝血管指数，研究假性剥脱综合征是否会影响动脉僵硬度。
这项横断面病例对照研究纳入了55例假性剥脱综合征患者和106例年龄及性别匹配的健康对照者。所有受试者均接受了双眼的全面眼科检查以及心踝血管指数测量。对所有患者进行了超声心动图和体重指数测量，并记录结果。采用二元回归模型确定心踝血管指数与假性剥脱之间的关系。
假性剥脱组与对照组在基线临床和人口统计学特征、左心室射血分数的超声心动图测量以及体重指数方面无显著差异。假性剥脱组的心踝血管指数平均值显著高于对照组（9.47±1.23 vs. 8.33±1.50，p<0.001）。假性剥脱组的眼压显著高于对照组（18.31±1.78 vs. 15.24±2.42 mmHg，p<0.05）。尽管逻辑回归分析显示心踝血管指数平均值和眼压值与假性剥脱综合征呈正相关（优势比（OR）分别为1.973，95%可信区间，1.051 - 3.706，p = 0.035；OR = 3.322，95%可信区间 = 2.000 - 5.520，p<0.001），但Pearson相关分析显示年龄与心踝血管指数平均值之间存在临界显著正相关，血脂异常与眼压以及心踝血管指数平均值之间存在显著正相关（r分别为0.265，p = 0.050；r = 0.337，p = 0.012；r = 0.433，p = 0.001）。
我们的研究结果表明，假性剥脱综合征患者的心踝血管指数值升高。
