Ozcan Sait Coskun, Ozcan Deniz Ozarslan
Department of Ophthalmology, Tayfur Ata Sökmen Faculty of Medicine, Mustafa Kemal University Hatay Turkey.
Arq Bras Oftalmol. 2023 Jan-Feb;86(1):7-12. doi: 10.5935/0004-2749.20230001.
The aim of this study was to evaluate the efficacy of a new-generation hybrid contact lens for improving visual outcomes and vision-related quality-of-life performance in patients with keratoconus who had intolerance or treatment failure of conventional correction methods such as the use of soft silicone-hydrogel or rigid gas-permeable contact lenses.
Twenty-eight patients with keratoconus (42 eyes) were enrolled in this prospective cross-sectional study. Airflex (Swisslens) lenses were fitted in the patients' eyes in accordance with the manufacturer's instruction. Ophthalmologic examinations, including manifest refraction, best-corrected distance visual acuity, slit-lamp biomicroscopy, and National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ-25) assessment, were performed at baseline and the 6-month visit.
An adequate fit was achieved in 39 eyes (92.9%) of 26 patients. Six eyes of 3 patients were excluded from the study owing to discontinuation of lens wearing. The mean age of the successful wearers was 20.3 ± 4.9 years. The mean best-corrected distance visual acuity was statistically significantly improved from 0.62 ± 0.30 to 0.11 ± 0.06 logMAR with the Airflex hybrid contact lenses (p<0.001). The mean overall composite NEI-VFQ-25 score statistically significantly increased with the Airflex hybrid contact lenses at the 6-month visit as compared with that at baseline (from 77.1 ± 16.3 to 90.9 ± 7.3, p=0.036). Statistically significantly better scores were obtained with the Airflex hybrid contact lenses in all the NEI-VFQ-25 subscale items (all p<0.05). No significant adverse effects were observed.
New-generation hybrid contact lenses can be used as an effective alternative for correction of irregular astigmatism in patients with keratoconus who have intolerance or treatment failure of conventional methods. Significant improvement in vision-related quality-of-life in patients with keratoconus can be achieved with these lenses.
本研究旨在评估新一代混合型隐形眼镜对圆锥角膜患者视觉效果及与视力相关的生活质量表现的改善效果，这些患者对传统矫正方法（如使用软性硅水凝胶或硬性透气性隐形眼镜）不耐受或治疗失败。
本前瞻性横断面研究纳入了28例圆锥角膜患者（42只眼）。按照制造商的说明为患者佩戴Airflex（Swisslens）镜片。在基线和6个月随访时进行眼科检查，包括显验光、最佳矫正远视力、裂隙灯显微镜检查以及美国国立眼科研究所视觉功能问卷25（NEI-VFQ-25）评估。
26例患者的39只眼（92.9%）实现了良好适配。3例患者的6只眼因停止佩戴镜片而被排除在研究之外。成功佩戴者的平均年龄为20.3±4.9岁。使用Airflex混合型隐形眼镜时，平均最佳矫正远视力从0.62±0.30 logMAR显著提高到0.11±0.06 logMAR（p<0.001）。与基线相比，在6个月随访时，使用Airflex混合型隐形眼镜的NEI-VFQ-25总体综合评分显著增加（从77.1±16.3提高到90.9±7.3，p=0.036）。在所有NEI-VFQ-25子量表项目中，Airflex混合型隐形眼镜均获得了统计学上显著更好的评分（所有p<0.05）。未观察到明显不良反应。
新一代混合型隐形眼镜可作为圆锥角膜患者矫正不规则散光的有效替代方法，这些患者对传统方法不耐受或治疗失败。使用这些镜片可显著改善圆锥角膜患者与视力相关的生活质量。
