Toth A, Beck F M, Beck E X, Flaxman N, Rosen S
J Dent Res. 1986 May;65(5):695-7. doi: 10.1177/00220345860650051301.
Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%), were evaluated for their efficacy in inhibiting root surface caries, bone loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-distilled water was used as a negative control group. Each rat was treated by having its molar teeth swabbed 2 X per day with the prescribed agent in its group for nine weeks. Root caries reduction in the minocycline and fluoride groups was not significantly different, but the reduction was significantly greater than in the 9-aminoacridine group, with the caries score in all three groups being significantly less than that in the water control. Bone loss reduction for the minocycline group was significantly greater than that for any other group.
评估了两种抗菌剂，即9-氨基吖啶（0.2%）和米诺环素（0.2%）对稻鼠根面龋、骨质流失和微生物群落的抑制效果。5000 ppm氟溶液用作抑制根面龋的阳性对照，双蒸水用作阴性对照组。每组大鼠的臼齿每天用规定的药剂擦拭2次，持续9周。米诺环素组和氟化物组的根龋减少量无显著差异，但均显著大于9-氨基吖啶组，三组的龋病评分均显著低于水对照组。米诺环素组的骨质流失减少量显著大于其他任何组。
