Dommerby H, Stangerup S E, Stangerup M, Hancke S
J Laryngol Otol. 1986 May;100(5):573-9. doi: 10.1017/s0022215100099680.
The present study aims at an assessment of hepato-splenomegaly in infectious mononucleosis (IM). In 29 patients admitted to the ENT department with IM, based on the typical clinical and laboratory findings, including a positive mononucleosis test in most cases, the size of the liver and spleen was estimated by ultrasonic scanning on days 1, 3, 5, 10, 20, 30, 90 and 120 after admission. A control group of eight patients with peritonsillar abscess was included for comparison. The results showed that all patients had an enlarged spleen (mean enlargement: 50-60 per cent) but only a few were palpable. Half of the patients had enlargement of the liver (5-20 per cent), which was palpable in only 8 per cent. There was no correlation between the size of the spleen and that of the liver, not between the changes in the size of these organs. There was no enlargement of the liver or spleen in the control group. No correlation was found between the size, or changes in the size, of the organs and blood values such as lactatdehydrogenase and aspartatamino-transferase. There is, however, a striking parallelism between the curves for these parameters, which might indicate that the organs as well as the blood tests return to normal within 28 days. If this holds true, our warning to abstain from physical exercise and alcoholic intake may be limited to a period of about 1 month.
本研究旨在评估传染性单核细胞增多症（IM）患者的肝脾肿大情况。29例因IM入住耳鼻喉科的患者，根据典型的临床和实验室检查结果（多数病例单核细胞增多试验呈阳性），在入院后第1、3、5、10、20、30、90和120天通过超声扫描估计肝脏和脾脏的大小。纳入8例扁桃体周围脓肿患者作为对照组进行比较。结果显示，所有患者均有脾脏肿大（平均肿大50% - 60%），但仅有少数可触及。半数患者有肝脏肿大（5% - 20%），其中仅有8%可触及。脾脏大小与肝脏大小之间、这些器官大小的变化之间均无相关性。对照组无肝脾肿大。未发现器官大小或大小变化与乳酸脱氢酶和天冬氨酸氨基转移酶等血液指标之间存在相关性。然而，这些参数的曲线之间存在显著的平行关系，这可能表明器官以及血液检查在28天内恢复正常。如果情况确实如此，我们关于避免体育锻炼和饮酒的警告可能仅限于约1个月的时间。
