Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, PR China.
Vaccine Clinical Evaluation Department, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, PR China.
Hum Vaccin Immunother. 2022 Dec 31;18(1):2026713. doi: 10.1080/21645515.2022.2026713. Epub 2022 Feb 16.
Rabies is a highly fatal zoonotic disease caused by the rabies virus invading the central nervous system. When suspected of exposure to the rabies virus, post-exposure prophylaxis should be administered as soon as possible. Monoclonal antibodies (mAbs) neutralizing the rabies virus could be better in human rabies post-exposure prophylaxis than equine or human rabies immune globulin in terms of supply, cost, and efficacy. This article reviews anti-rabies mAbs produced by multiple techniques, and the results of clinical trials for anti-rabies mAbs cocktails recognizing non-overlapping epitopes are also discussed.
狂犬病是一种由狂犬病病毒入侵中枢神经系统引起的高致命性人畜共患病。当怀疑接触狂犬病病毒时，应尽快进行暴露后预防。单克隆抗体（mAbs）中和狂犬病病毒在人类狂犬病暴露后预防方面可能优于马或人狂犬病免疫球蛋白，无论是在供应、成本还是疗效方面。本文综述了多种技术生产的抗狂犬病 mAbs，还讨论了针对非重叠表位的抗狂犬病 mAbs 鸡尾酒的临床试验结果。
