Liu Cheng, Lv Xinjun, Liu Si, Chen Qingjun, Zhu Zhenggang, Yu Rui, Yin Wenwu, Wang Chuanlin
Department of Emergency, Peking University First Hospital, Beijing, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2508559. doi: 10.1080/21645515.2025.2508559. Epub 2025 May 26.
Rabies is a fatal zoonotic infectious disease primarily caused by the rabies virus. Anti-rabies monoclonal antibody (mAb) is developed using modern genetic engineering technology. However, no bibliometric assessment has been conducted to evaluate the scientific progress in this area. A search of articles in the Web of Science (WoS) from January 1, 1991, to November 17, 2024, yielded 455 papers that were analyzed using various online analysis tools. The cumulative publications from 1991 to 2023 followed a linear distribution. The United States and China led this research initiative. Keywords were divided into two clusters, including "monoclonal-antibody" and "post-exposure prophylaxis." This systematic bibliometric analysis of the literature on anti-rabies monoclonal antibodies will help to reveal the internal relationship of the whole research and development network and promote the perfection of related research and development work to a considerable extent. This study not only delineates the historical trajectory and current status of mAb research but also provides valuable insights and concrete recommendations for future directions.
狂犬病是一种主要由狂犬病毒引起的致命性人畜共患传染病。抗狂犬病单克隆抗体（mAb）是利用现代基因工程技术研制的。然而，尚未进行文献计量学评估来评价该领域的科学进展。检索科学网（WoS）中1991年1月1日至2024年11月17日的文章，得到455篇论文，并使用各种在线分析工具对其进行分析。1991年至2023年的累积出版物呈线性分布。美国和中国引领了这项研究工作。关键词分为两个聚类，包括“单克隆抗体”和“暴露后预防”。这种对抗狂犬病单克隆抗体文献的系统文献计量学分析将有助于揭示整个研发网络的内在关系，并在很大程度上促进相关研发工作的完善。本研究不仅描绘了单克隆抗体研究的历史轨迹和现状，还为未来方向提供了有价值的见解和具体建议。
