Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of clinical pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Pediatr Res. 2022 Nov;92(5):1432-1436. doi: 10.1038/s41390-022-01978-0. Epub 2022 Feb 16.
Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study's objective was to estimate the variations in the population of CD4CD25 FoxP3 cells (CD4 regulatory T-lymphocytes; Tregs) in previously untreated children with chronic ITP managed in Assiut University Hospitals, as well as to evaluate the efficacy of high-dose dexamethasone (HD-DXM) in these patients.
In this study, we investigated the frequencies of T-lymphocyte subsets in 27 untreated children with chronic ITP.
Prior to treatment, the percentages of CD4CD25 cells and Tregs were significantly lower in the chronic ITP group compared to the control group (p = 0.018 and p < 0.0001, respectively). After treatment with HD-DXM, Tregs and platelets were significantly increased in these patients (p < 0.0001 for both).
Our results suggest that Tregs are deficient in children with chronic ITP and that HD-DXM immunosuppressive therapy can restore the levels of these cells.
CD4CD25 cells and Tregs were significantly lower in children chronic ITP compared to healthy control. HD-DXM treatment led to significantly increased Tregs and platelets in these patients. Our results suggest that Tregs are deficient in children with chronic ITP and that HD-DXM immunosuppressive therapy can restore the levels of these cells.
免疫性血小板减少症（ITP）是一种获得性自身免疫性疾病。本研究的目的是评估未接受治疗的慢性 ITP 患儿的 CD4CD25 FoxP3 细胞（CD4 调节性 T 淋巴细胞；Tregs）群体变化，并评估大剂量地塞米松（HD-DXM）在这些患者中的疗效。
本研究调查了 27 例未经治疗的慢性 ITP 患儿的 T 淋巴细胞亚群频率。
在治疗前，慢性 ITP 组的 CD4CD25 细胞和 Tregs 的百分比明显低于对照组（p=0.018 和 p<0.0001）。在接受 HD-DXM 治疗后，这些患者的 Tregs 和血小板显著增加（两者均 p<0.0001）。
我们的结果表明，慢性 ITP 患儿的 Tregs 存在缺陷，HD-DXM 免疫抑制治疗可以恢复这些细胞的水平。
与健康对照组相比，慢性 ITP 患儿的 CD4CD25 细胞和 Tregs 明显降低。HD-DXM 治疗可使这些患者的 Tregs 和血小板显著增加。我们的结果表明，Tregs 在慢性 ITP 患儿中存在缺陷，HD-DXM 免疫抑制治疗可以恢复这些细胞的水平。
