一种关于局部脑灌注压指数的新提议——基于流体动力学的理论方法
A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach Using Fluid Dynamics.
作者信息
Kameyama Masashi, Momose Toshimitsu, Ishibashi Kenji, Ishii Kenji
机构信息
Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
Department of Nuclear Medicine, Graduate School of Medicine, The International University of Health and Welfare, Narita, Japan.
出版信息
Front Neurol. 2022 Jan 31;12:765463. doi: 10.3389/fneur.2021.765463. eCollection 2021.
Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [O] HO/ CO and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future.
通过[氧]氢/一氧化碳和一氧化碳正电子发射断层扫描（PET）检查得出的脑血流量（CBF）/脑血容量（CBV）比值已被用作脑灌注压（CPP）的指标。在狒狒中，CBF/CBV被证明与平均动脉压（MAP）相关。然而，该公式尚未被证实与CPP成比例。我们基于一个简单模型，利用泊肃叶方程开发了一种新的CPP指标。我们的模型表明，CBF/CBV与CPP成比例，并且在数学上它是比CBF/CBV更准确的指标。这个新指标未来需要进行实验验证。
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