尼莫地平联合氟桂利嗪治疗血管神经性头痛患者的安全性和有效性
Safety and efficacy of nimodipine combined with flunarizine in patients with angioneurotic headache.
作者信息
Zhang Tao, Xiao Yao, Li Shengquan
机构信息
Department of Neurology, Qijiang District People's Hospital Qijiang 401420, Chongqing, China.
Medical Equipment Department of Chongqing Qijiang District People's Hospital Qijiang 401420, Chongqing, China.
出版信息
Am J Transl Res. 2022 Jan 15;14(1):511-517. eCollection 2022.
OBJECTIVE
To observe the role of nimodipine combined with flunarizine on angioneurotic headache.
METHODS
Altogether 101 patients with angioneurotic headache were divided into the control group (CG, n=51) and the therapy group (TG, n=50). Patients in the CG were given nimodipine, while patients in the TG were given flunarizine on the basis of nimodipine. The clinical efficacy and adverse reactions of patients were observed.
RESULTS
After treatment, the Visual analog scale (VAS) scores of the TG were markedly lower than those in the CG, and the number of attacks and headache duration of patients in the TG were also markedly reduced. Observation of the clinical efficacy showed that the effective rate of the TG was markedly higher than that of the CG, but no additional adverse reactions were found. In addition, after treatment, the cerebral hemodynamics and quality of life of patients were improved.
CONCLUSION
Nimodipine combined with flunarizine can better promote the recovery of patients with angioneurotic headache and improve their quality of life.
目的
观察尼莫地平联合氟桂利嗪治疗血管神经性头痛的作用。
方法
将101例血管神经性头痛患者分为对照组（CG，n = 51）和治疗组（TG，n = 50）。对照组患者给予尼莫地平，治疗组患者在尼莫地平基础上给予氟桂利嗪。观察患者的临床疗效及不良反应。
结果
治疗后，治疗组视觉模拟评分（VAS）明显低于对照组，治疗组患者发作次数及头痛持续时间也明显减少。临床疗效观察显示，治疗组有效率明显高于对照组，但未发现额外不良反应。此外，治疗后患者脑血流动力学及生活质量得到改善。
结论
尼莫地平联合氟桂利嗪能更好地促进血管神经性头痛患者康复，提高其生活质量。
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