氟桂利嗪联合银杏叶提取物及双嘧达莫注射液对老年眩晕患者血液流变学的影响

Effects of flunarizine combined with ginkgo leaf extract and dipyridamole injection on hemorheology in elderly patients with vertigo.

作者信息

Liu Xinlei, Shu Lingyu, Zheng Junxia

机构信息

Xinlei Liu, Department of Neurology, The First People's Hospital of Lin'an District, Hangzhou, Zhejiang Province 311300, P.R. China.

Lingyu Shu, Health Management Center, The First People's Hospital of Lin'an District, Hangzhou, Zhejiang Province 311300, P.R. China.

出版信息

Pak J Med Sci. 2024 Jan-Feb;40(3Part-II):337-341. doi: 10.12669/pjms.40.3.8456.

DOI:10.12669/pjms.40.3.8456

PMID:38356833

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10862431/

Abstract

OBJECTIVE

To investigate the effect of flunarizine combined with ginkgo leaf extract and dipyridamole injection (GDI) on hemorheology of elderly patients with vertigo.

METHODS

Clinical data of 105 elderly patients with vertigo who were treated in The First People's Hospital of Lin'an District from June 2019 to December 2022 were retrospectively selected. Of them, 54 patients received flunarizine combined with GDI (Study group) while 51 patients received flunarizine treatment alone (Control group). The treatment effect and adverse reactions of the two groups, functional rehabilitation before and after treatment, including the Simplified Vertigo Symptom Score Scale (VSS-SF), Berg Balance Scale (BBS), and Dizziness Handicap Inventory (DHI) were measured. Hemodynamics including blood flow velocity (Vm) of basilar artery (BA), left vertebral artery (LVA), and right vertebral artery (RVA) before and after treatment were also assessed.

RESULTS

The total efficacy of the treatment in the study group was higher than that in the control group (94.4 % . 75.9%; P<0.05). After the treatment, the Vm of the BA, LVA, and RVA was increased in both groups compared to before treatment, and the increase was greater in the study group than in the control group (P<0.05). In addition, the BBS scores of the two groups after the treatment were higher than before the treatment, while the DHI and VSS-SF scores were lower than before the treatment. BBS scores of the study group were higher than those of the control group, while the DHI and VSS-SF scores were lower than those of the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the study group (5.6%) and the control group (2.0%; P>0.05).

CONCLUSIONS

The combination of flunarizine and GDI in elderly patients with vertigo can effectively regulate hemodynamics of the patient, reduce the degree of vertigo, improve balance, and have a significant overall therapeutic effect without increasing the risk of adverse reactions.

摘要

目的

探讨氟桂利嗪联合银杏叶提取物双嘧达莫注射液（GDI）对老年眩晕患者血液流变学的影响。

方法

回顾性选取2019年6月至2022年12月在临安区第一人民医院治疗的105例老年眩晕患者的临床资料。其中，54例患者接受氟桂利嗪联合GDI治疗（研究组），51例患者仅接受氟桂利嗪治疗（对照组）。测量两组的治疗效果和不良反应、治疗前后的功能康复情况，包括简易眩晕症状评分量表（VSS-SF）、伯格平衡量表（BBS）和头晕残障量表（DHI）。还评估了治疗前后包括基底动脉（BA）、左椎动脉（LVA）和右椎动脉（RVA）血流速度（Vm）在内的血流动力学情况。

结果

研究组治疗总有效率高于对照组（94.4% 对75.9%；P<0.05）。治疗后，两组BA、LVA和RVA的Vm均较治疗前升高，且研究组升高幅度大于对照组（P<0.05）。此外，两组治疗后的BBS评分均高于治疗前，而DHI和VSS-SF评分低于治疗前。研究组的BBS评分高于对照组，而DHI和VSS-SF评分低于对照组（P<0.05）。研究组（5.6%）和对照组（2.0%）不良反应发生率差异无统计学意义（P>0.05）。