Nishioka Kazue, Koizumi Akiko, Takita Yuko
Joy Dermatological Clinic, Sanyo-Onoda, Yamaguchi, Japan.
J Dermatol. 2022 May;49(5):515-518. doi: 10.1111/1346-8138.16325. Epub 2022 Feb 16.
Stearyl alcohol is found in various cosmetics and topical medications and is regarded as safe. Allergic contact dermatitis is reported due to this chemical on rare occasions. We report seven cases, comprising three men and four women aged between 36 and 62 between the years 2013 to 2019, of allergic contact dermatitis due to the use of topical medication, where the patient showed a positive result to a patch test using stearyl alcohol. There were 10 topical medications that we considered to be the cause of this: three were from Oronine H ointment, two from Eurax cream, one from Eurax H cream, and four from topical antifungal medications. All these medications contained stearyl alcohol. Seven cases of patch tests with stearyl alcohol all showed positive results. Moreover, having done a patch test with cetyl alcohol, two out of three tests showed positive. When researching allergic contact dermatitis due to topical medications, it is important to test for allergy to stearyl alcohol as well as their main ingredients, because it is contained in numerous products and has the ability to cause allergic contact dermatitis.
硬脂醇存在于各种化妆品和外用药物中，被认为是安全的。在极少数情况下，有因这种化学物质导致过敏性接触性皮炎的报告。我们报告了7例病例，包括2013年至2019年间年龄在36岁至62岁之间的3名男性和4名女性，他们因使用外用药物而发生过敏性接触性皮炎，患者对使用硬脂醇进行的斑贴试验呈阳性结果。我们认为有10种外用药物是导致这种情况的原因：3种来自奥罗宁H软膏，2种来自优力肤霜，1种来自优力肤H霜，4种来自外用抗真菌药物。所有这些药物都含有硬脂醇。7例用硬脂醇进行的斑贴试验均呈阳性结果。此外，用鲸蜡醇进行斑贴试验时，3次试验中有2次呈阳性。在研究外用药物引起的过敏性接触性皮炎时，除了检测其主要成分的过敏情况外，检测对硬脂醇的过敏也很重要，因为它存在于众多产品中，并且有导致过敏性接触性皮炎的能力。
