Tosti A, Vincenzi C, Guerra L, Andrisano E
Department of Dermatology, University of Bologna, Italy.
Contact Dermatitis. 1996 Nov;35(5):287-9. doi: 10.1111/j.1600-0536.1996.tb02390.x.
The aim of this study was to investigate the frequency of sensitization to fatty alcohols in a group of patients with suspected cosmetic or medicament contact dermatitis. From May 1992 to September 1995, we patch tested a series of 5 fatty alcohols on 146 patients. These included 108 females and 38 males aged from 13 to 72 years (mean age 42.5). These patients, who had previously been tested with the GIRDCA standard series, were selected because their clinical lesions or histories indicated topical preparations as the possible source of their contact dermatitis. High-grade fatty alcohols (> 99% pure) were used for testing. 34 patients (23.2%), 25 female and 9 male aged from 14 to 72 years, showed a positive patch test to fatty alcohols, 33 of them to oleyl alcohol. A total of 39 reactions were detected with 5 patients showing more than 1 positive reaction. Our results show that sensitization to oleyl alcohol is not rare in patients with contact dermatitis due to cosmetics or topical medicaments.
本研究的目的是调查一组疑似化妆品或药物接触性皮炎患者中对脂肪醇过敏的频率。1992年5月至1995年9月，我们对146例患者进行了一系列5种脂肪醇的斑贴试验。其中包括108名女性和38名男性，年龄在13至72岁之间（平均年龄42.5岁）。这些患者之前曾接受过GIRDCA标准系列测试，选择他们是因为其临床皮损或病史提示局部用药可能是其接触性皮炎的病因。使用高纯度脂肪醇（纯度>99%）进行测试。34例患者（23.2%），25名女性和9名男性，年龄在14至72岁之间，对脂肪醇斑贴试验呈阳性，其中33例对油醇呈阳性。共检测到39例反应，5例患者有不止1次阳性反应。我们的结果表明，在因化妆品或局部用药引起接触性皮炎的患者中，对油醇过敏并不罕见。
