Burkovskaia T E
Kosm Biol Aviakosm Med. 1986 Mar-Apr;20(2):83-6.
Bone marrow cells were implanted into the capsule of the kidney of mice which were then given intraperitoneal injections of hydrocortisone in the dose of 5 mg per animal. The drug influenced different stages of bone histogenesis in a different manner. The stage of the onset of bone formation proved to be most sensitive, whereas the earlier and later stages were less sensitive to hydrocortisone. It is concluded that the target cells for hydrocortisone are osteoblasts at the stage of active synthesis of bone proteins rather than cells-precursors of osteogenesis.
将骨髓细胞植入小鼠肾脏被膜内，然后给每只动物腹腔注射5毫克氢化可的松。该药物对骨组织发生的不同阶段有不同影响。结果表明，骨形成开始阶段最为敏感，而早期和后期对氢化可的松的敏感性较低。结论是，氢化可的松的靶细胞是处于骨蛋白活跃合成阶段的成骨细胞，而不是骨生成的细胞前体。
