Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China.
Org Biomol Chem. 2022 Mar 2;20(9):1958-1968. doi: 10.1039/d2ob00019a.
The transition-metal-free alkylation/cyclization of activated alkenes using Hantzsch ester derivatives as effective alkyl reagents is described. A wide variety of valuable oxindoles was constructed in a single step with excellent selectivity. The reaction occurs through the formation of alkyl radical species followed by the tandem addition/annulation of olefins under oxidative conditions. This protocol is expected to offer inspiration for developing novel and efficient applications of Hantzsch esters in organic synthesis.
本文描述了使用 Hantzsch 酯衍生物作为有效烷基试剂，实现了无过渡金属的活化烯烃的烷基化/环化反应。该反应具有优异的选择性，可一步构建多种有价值的氧茚满衍生物。反应通过形成烷基自由基物种，然后在氧化条件下通过烯烃的串联加成/环化进行。该方案有望为 Hantzsch 酯在有机合成中的新型、高效应用提供启示。
