手性 - 六氢 - 咔啉衍生物的对映选择性合成 Ir 催化不对称氢化。
Enantioselective synthesis of -hexahydro--carboline derivatives Ir-catalyzed asymmetric hydrogenation.
机构信息
Medi-X Pingshan, Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, 518000, People's Republic of China.
Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518000, People's Republic of China.
出版信息
Chem Commun (Camb). 2022 Mar 8;58(20):3286-3289. doi: 10.1039/d1cc06888a.
A novel synthetic route was developed for the construction of a chiral -hexahydro-γ-carboline derivative through Ir/ZhaoPhos-catalyzed asymmetric hydrogenation of corresponding tetrahydro-γ-carboline with high yields (up to 99% yield), excellent diastereoselectivities (up to >99 : 1 dr) and enantioselectivities (up to 99% ee), and high substrate-to-catalyst ratios (up to 5000).
开发了一种通过 Ir/ZhaoPhos 催化相应的四氢-γ-咔啉的不对称氢化来构建手性-六氢-γ-咔啉衍生物的新型合成路线，具有高产率（高达 99%的产率）、优异的非对映选择性（高达>99:1 dr）和对映选择性（高达 99%ee），以及高的底物-催化剂比（高达 5000）。
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