对映体富集的邻位卤代醇的高效合成：使用动态动力学拆分的铱催化不对称氢化反应
Highly efficient synthesis of enantioenriched vicinal halohydrins Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution.
作者信息
He Bin, Chen Gen-Qiang, Zhang Xumu
机构信息
Institute of Zhejiang University-Quzhou, Quzhou, 324000, China.
Academy for Advanced Interdisciplinary Studies and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, People's Republic of China.
出版信息
Chem Commun (Camb). 2024 Sep 5;60(72):9785-9788. doi: 10.1039/d4cc02529f.
A novel synthetic route was developed for the construction of chiral -vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding α-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 : 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000).
通过铱/手性膦酰胺催化相应α-卤代酮的不对称氢化反应，开发了一种新型合成路线用于构建手性邻位卤代醇衍生物，该反应具有高收率（高达99%）、优异的非对映选择性（>20:1 dr）、对映选择性（高达99% ee）以及高底物催化剂比（S/C = 1000）。
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